Coinfection Alters the Playing Field: Herpesviruses Induce Acyclovir to Inhibit HIV

Jack T. Stapleton, Henry H. Balfour

Research output: Contribution to journalShort survey

4 Scopus citations

Abstract

The antiherpes drug acyclovir was found to inhibit HIV following its phosphorylation by human herpesviruses, providing a hypothesis to explain the observed beneficial effects of acyclovir therapy on HIV viral load and HIV disease progression. This report underscores the importance of studying HIV in the context of microbial copathogens.

Original languageEnglish (US)
Pages (from-to)194-195
Number of pages2
JournalCell Host and Microbe
Volume4
Issue number3
DOIs
StatePublished - Sep 11 2008

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