Coiled-coil peptide-based assembly of gold nanoparticles

Molly M. Stevens; Nolan T. Flynn; Chun Wang; David A. Tirrell; Robert Langer

doi:10.1002/adma.200306430

Coiled-coil peptide-based assembly of gold nanoparticles

Molly M. Stevens, Nolan T. Flynn, Chun Wang, David A. Tirrell, Robert Langer

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

150 Scopus citations

Abstract

The Coiled-coil-based assembly of gold nanoparticles was analyzed. Varying the peptide sequence to produce coiled coils with different stabilities make flexibility in design easy. Hydrophobic packing at the interface between the peptides is the dominant force of stabilization of the coiled-coil structure. The stability of the coiled coils is modulated by electrostatic interactions across the interface of adjacent helices arising from the side chains of amino acids.

Original language	English (US)
Pages (from-to)	915-918
Number of pages	4
Journal	Advanced Materials
Volume	16
Issue number	11
DOIs	https://doi.org/10.1002/adma.200306430
State	Published - Jun 4 2004

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10.1002/adma.200306430

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title = "Coiled-coil peptide-based assembly of gold nanoparticles",

abstract = "The Coiled-coil-based assembly of gold nanoparticles was analyzed. Varying the peptide sequence to produce coiled coils with different stabilities make flexibility in design easy. Hydrophobic packing at the interface between the peptides is the dominant force of stabilization of the coiled-coil structure. The stability of the coiled coils is modulated by electrostatic interactions across the interface of adjacent helices arising from the side chains of amino acids.",

author = "Stevens, {Molly M.} and Flynn, {Nolan T.} and Chun Wang and Tirrell, {David A.} and Robert Langer",

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AU - Flynn, Nolan T.

AU - Wang, Chun

AU - Tirrell, David A.

AU - Langer, Robert

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Coiled-coil peptide-based assembly of gold nanoparticles

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