Cohort profile: The ECHO prenatal and early childhood pathways to health consortium (ECHO-PATHWAYS)

Kaja Z. LeWinn, Catherine J. Karr, Marnie Hazlehurst, Kecia Carroll, Christine Loftus, Ruby Nguyen, Emily Barrett, Shanna H. Swan, Adam A. Szpiro, Alison Paquette, Paul Moore, Elizabeth Spalt, Lisa Younglove, Alexis Sullivan, Trina Colburn, Nora Byington, Lauren Sims Taylor, Stacey Moe, Sarah Wang, Alana CordeiroAria Mattias, Jennifer Powell, Tye Johnson, Amanda Norona-Zhou, Alex Mason, Nicole R. Bush, Sheela Sathyanarayana

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Purpose Exposures early in life, beginning in utero, have long-term impacts on mental and physical health. The ECHO prenatal and early childhood pathways to health consortium (ECHO-PATHWAYS) was established to examine the independent and combined impact of pregnancy and childhood chemical exposures and psychosocial stressors on child neurodevelopment and airway health, as well as the placental mechanisms underlying these associations. Participants The ECHO-PATHWAYS consortium harmonises extant data from 2684 mother-child dyads in three pregnancy cohort studies (CANDLE [Conditions Affecting Neurocognitive Development and Learning in Early Childhood], TIDES [The Infant Development and Environment Study] and GAPPS [Global Alliance to Prevent Prematurity and Stillbirth]) and collects prospective data under a unified protocol. Study participants are socioeconomically diverse and include a large proportion of Black families (38% Black and 51% White), often under-represented in research. Children are currently 5-15 years old. New data collection includes multimodal assessments of primary outcomes (airway health and neurodevelopment) and exposures (air pollution, phthalates and psychosocial stress) as well as rich covariate characterisation. ECHO-PATHWAYS is compiling extant and new biospecimens in a central biorepository and generating the largest placental transcriptomics data set to date (N=1083). Findings to date Early analyses demonstrate adverse associations of prenatal exposure to air pollution, phthalates and maternal stress with early childhood airway outcomes and neurodevelopment. Placental transcriptomics work suggests that phthalate exposure alters placental gene expression, pointing to mechanistic pathways for the developmental toxicity of phthalates. We also observe associations between prenatal maternal stress and placental corticotropin releasing hormone, a marker of hormonal activation during pregnancy relevant for child health. Other publications describe novel methods for examining exposure mixtures and the development of a national spatiotemporal model of ambient outdoor air pollution. Future plans The first wave of data from the unified protocol (child age 8-9) is nearly complete. Future work will leverage these data to examine the combined impact of early life social and chemical exposures on middle childhood health outcomes and underlying placental mechanisms.

Original languageEnglish (US)
Article numbere064288
JournalBMJ open
Volume12
Issue number10
DOIs
StatePublished - Oct 21 2022

Bibliographical note

Funding Information:
Research reported in this publication was supported by the ECHO-PATHWAYS consortium (NIH grants: UG300023271 and UH3OD023271), NIH grant P30ES007033 and NCATS/NIH grants: UL1 TR002319, KL2 TR002317 and TL1 TR002318. The CANDLE study is also funded by the Urban Child Institute, NIH grant 1R01HL109977, R01HL132338 and CIHR award number MWG-146331. The TIDES study is also supported by the NIH Office of Director (UG3OD023305 and UH3OD023305), NIEHS intramural funding ZIA10331 and NIH grants: R01ES016863 and R01ES25169. Air pollution data were developed under STAR research assistance agreements, RD831697 (MESA Air), RD-83830001 (MESA Air Next Stage), RD83479601 (UW Center for Clean Air Research) and R83374101 (MESA Coarse), awarded by the US Environmental Protection Agency (EPA). The views expressed in this document are solely those of the authors and the EPA does not endorse any products or commercial services mentioned in this publication. This publication has not been formally reviewed by the EPA. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This manuscript has been reviewed by ECHO-PATHWAYS for scientific content and consistency of data interpretation with previous ECHO-PATHWAYS publications.

Funding Information:
Research reported in this publication was supported by the ECHO-PATHWAYS consortium (NIH grants: UG300023271 and UH3OD023271), NIH grant P30ES007033 and NCATS/NIH grants: UL1 TR002319, KL2 TR002317 and TL1 TR002318. The CANDLE study is also funded by the Urban Child Institute, NIH grant 1R01HL109977, R01HL132338 and CIHR award number MWG-146331. The TIDES study is also supported by the NIH Office of Director (UG3OD023305 and UH3OD023305), NIEHS intramural funding ZIA10331 and NIH grants: R01ES016863 and R01ES25169. Air pollution data were developed under STAR research assistance agreements, RD831697 (MESA Air), RD-83830001 (MESA Air Next Stage), RD83479601.

Publisher Copyright:
© Author(s) (or their employer(s)) 2022.

Keywords

  • developmental neurology & neurodisability
  • fetal medicine
  • paediatric thoracic medicine
  • public health

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