Cohn Changes in Serologic Reactivity of Endotoxin Induced by Fraction IV1 xof Normal Human Serum

Jon A. Rudbach; Arthur G. Johnson

doi:10.3181/00379727-111-27882

Cohn Changes in Serologic Reactivity of Endotoxin Induced by Fraction IV₁ xof Normal Human Serum

Jon A. Rudbach
, Arthur G. Johnson

Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A substantial loss in the ability of endotoxin to be precipitated by homologous antibody occurs following incubation with Fraction IV₁ derived from normal human serum by cold ethanol fractionation. Evidence is presented that this loss in serologic reactivity is not associated with release of the major determinant sugar, per se. Rather, immunodiffusion analysis revealed the dispersion of a major antigen, with formation of a more rapidly migrating component. The latter was shown to form a line of identity with the O polysaccharide hapten.

Original language	English (US)
Pages (from-to)	651-655
Number of pages	5
Journal	Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
Volume	111
Issue number	3
DOIs	https://doi.org/10.3181/00379727-111-27882
State	Published - Dec 1962

Bibliographical note

Funding Information:
Supported by grants from USPHS and The Upjohn Co., Kalamazoo, Mich.

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10.3181/00379727-111-27882

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Cohn Changes in Serologic Reactivity of Endotoxin Induced by Fraction IV₁ xof Normal Human Serum. / Rudbach, Jon A.; Johnson, Arthur G.
In: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.), Vol. 111, No. 3, 12.1962, p. 651-655.

Research output: Contribution to journal › Article › peer-review

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