Cohn Changes in Serologic Reactivity of Endotoxin Induced by Fraction IV1 xof Normal Human Serum

Jon A. Rudbach, Arthur G. Johnson

Research output: Contribution to journalArticlepeer-review


A substantial loss in the ability of endotoxin to be precipitated by homologous antibody occurs following incubation with Fraction IV1 derived from normal human serum by cold ethanol fractionation. Evidence is presented that this loss in serologic reactivity is not associated with release of the major determinant sugar, per se. Rather, immunodiffusion analysis revealed the dispersion of a major antigen, with formation of a more rapidly migrating component. The latter was shown to form a line of identity with the O polysaccharide hapten.

Original languageEnglish (US)
Pages (from-to)651-655
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number3
StatePublished - Dec 1962

Bibliographical note

Funding Information:
Supported by grants from USPHS and The Upjohn Co., Kalamazoo, Mich.

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