Cognitive interventions targeting brain plasticity in the prodromal and early phases of schizophrenia

Melissa Fisher, Rachel Loewy, Kate Hardy, Danielle Schlosser, Sophia Vinogradov

Research output: Contribution to journalReview articlepeer-review

67 Scopus citations


Several important paradigm shifts have occurred in the field of schizophrenia treatment, including an increased focus on early detection, the development of preemptive interventions, and the view of schizophrenia as a neurodevelopmental disease characterized by decreased efficiency and abnormal connectivity in cortical and subcortical neural networks. In this review, we briefly describe some of the neural impairments that contribute to the development of schizophrenia, with an emphasis on the impact of stress and trauma on cognitively vulnerable neural systems. We then present current data on two behavioral interventions that target these critical risk factors and that aim to preempt the onset of schizophrenia in vulnerable individuals or improve the clinical course in recent-onset schizophrenia: cognitive therapy and computerized cognitive training.

Original languageEnglish (US)
Pages (from-to)435-463
Number of pages29
JournalAnnual Review of Clinical Psychology
StatePublished - Mar 2013


  • clinical high risk
  • cognitive therapy
  • cognitive training
  • neuroplasticity
  • recent-onset schizophrenia
  • ultra high risk


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