Cognitive deficits distinguish patients with adolescent- and adult-onset schizophrenia

Michael R. Basso, Henry A. Nasrallah, Stephen C. Olson, Robert A. Bornstein

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Recent studies have shown that patients with schizophrenia who have an adolescent-symptom onset (before age 21) have a worse clinical course and greater frequency of cerebral abnormalities than those with an adult-onset (after age 25). However, Little is known about the neuropsychological functioning of these groups. A comprehensive neuropsychological examination was administered to groups of patients with schizophrenia with either an adolescent- or adult symptom-onset and a healthy control group. The adolescent-onset group performed worse than the adult-onset and control groups, particularly on measures of memory and executive function. The adult-onset:group also performed worse than the controls, but to a lesser extent than did the adolescent-onset group. Results are discussed with reference to hypotheses that adolescent-onset schizophrenia represents a distinct neurodevelopmental disease entity.

Original languageEnglish (US)
Pages (from-to)107-112
Number of pages6
JournalNeuropsychiatry, Neuropsychology and Behavioral Neurology
Issue number2
StatePublished - May 30 1997


  • Executive function
  • Memory
  • Schizophrenia


Dive into the research topics of 'Cognitive deficits distinguish patients with adolescent- and adult-onset schizophrenia'. Together they form a unique fingerprint.

Cite this