Cognitive collaborations: Bidirectional functional connectivity between the cerebellum and the hippocampus

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Abstract

There is a growing recognition that the utility of the cerebellum is not limited to motor control. This review focuses on the particularly novel area of hippocampal-cerebellar interactions. Recent work has illustrated that the hippocampus and cerebellum are functionally connected in a bidirectional manner such that the cerebellum can influence hippocampal activity and vice versa. This functional connectivity has important implications for physiology, including spatial navigation and timing-dependent tasks, as well as pathophysiology, including seizures. Moving forward, an improved understanding of the critical biological underpinnings of these cognitive collaborations may improve interventions for neurological disorders such as epilepsy.

Original languageEnglish (US)
Article number177
JournalFrontiers in Systems Neuroscience
Volume9
Issue numberDEC
DOIs
StatePublished - Dec 22 2015

Bibliographical note

Funding Information:
This work was supported by a MnDrive Post-doctoral Fellowship in Neuromodulation (to WY), MnDrive Neuromodulation Scholar Funds (to EK), and a National Institutes of Health grant (R00 NS087110, to EK). The authors would also like to thank two lab members, Zachary Zeidler and Isabelle Febvre, for aiding in the editing of this paper.

Publisher Copyright:
© 2015 Yu and Krook-Magnuson.

Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.

Keywords

  • Cerebellum
  • Connectivity
  • Epilepsy
  • Hippocampus
  • Spatial
  • Temporal

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