Cognitive and physical factors affecting daily function in Alzheimer's disease

A cross-sectional analysis

Fang Yu, Yan Chen, Michelle A. Mathiason, Qiaoqin Wan, Feng V. Lin

Research output: Contribution to journalArticle

Abstract

Understanding the factors affecting activities of daily living (ADL) is important in Alzheimer's disease (AD), because decline in ADL contributes to many poor health outcomes. Existing studies often investigate the factors in isolation without a theoretical framework. The purpose of the present study was to provide preliminary results on how cognition, physical performance, and behavioral and psychological symptoms of dementia mediate the relationship of aerobic fitness and ADL in AD. A cross-sectional analysis was used (n = 28: average age 78 [8] years, education 16 (3) years, Mini-Mental State Examination scores 20 [4]). The results showed that aerobic fitness is not linked to ADL directly, and its association with ADL was mediated by physical performance and global cognition. Our findings provide preliminary support for aerobic fitness as a potential therapeutic target, as enhanced aerobic fitness could simultaneously modify other factors affecting ADL. Nurses are in a unique position for coordinating exercise safety assessment and prescription and educating older adults with AD about exercise participation.

Original languageEnglish (US)
Pages (from-to)14-20
Number of pages7
JournalNursing and Health Sciences
Volume21
Issue number1
DOIs
StatePublished - Mar 1 2019

Fingerprint

Activities of Daily Living
Alzheimer Disease
Cross-Sectional Studies
Cognition
Exercise
Behavioral Symptoms
Prescriptions
Dementia
Nurses
Psychology
Safety
Education
Health

Keywords

  • Alzheimer's disease
  • activities of daily living
  • aerobic fitness
  • cognition
  • dementia

Cite this

Cognitive and physical factors affecting daily function in Alzheimer's disease : A cross-sectional analysis. / Yu, Fang; Chen, Yan; Mathiason, Michelle A.; Wan, Qiaoqin; Lin, Feng V.

In: Nursing and Health Sciences, Vol. 21, No. 1, 01.03.2019, p. 14-20.

Research output: Contribution to journalArticle

@article{60af1a812e56411e93ec303f1dffbc32,
title = "Cognitive and physical factors affecting daily function in Alzheimer's disease: A cross-sectional analysis",
abstract = "Understanding the factors affecting activities of daily living (ADL) is important in Alzheimer's disease (AD), because decline in ADL contributes to many poor health outcomes. Existing studies often investigate the factors in isolation without a theoretical framework. The purpose of the present study was to provide preliminary results on how cognition, physical performance, and behavioral and psychological symptoms of dementia mediate the relationship of aerobic fitness and ADL in AD. A cross-sectional analysis was used (n = 28: average age 78 [8] years, education 16 (3) years, Mini-Mental State Examination scores 20 [4]). The results showed that aerobic fitness is not linked to ADL directly, and its association with ADL was mediated by physical performance and global cognition. Our findings provide preliminary support for aerobic fitness as a potential therapeutic target, as enhanced aerobic fitness could simultaneously modify other factors affecting ADL. Nurses are in a unique position for coordinating exercise safety assessment and prescription and educating older adults with AD about exercise participation.",
keywords = "Alzheimer's disease, activities of daily living, aerobic fitness, cognition, dementia",
author = "Fang Yu and Yan Chen and Mathiason, {Michelle A.} and Qiaoqin Wan and Lin, {Feng V.}",
year = "2019",
month = "3",
day = "1",
doi = "10.1111/nhs.12426",
language = "English (US)",
volume = "21",
pages = "14--20",
journal = "Nursing and Health Sciences",
issn = "1441-0745",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Cognitive and physical factors affecting daily function in Alzheimer's disease

T2 - A cross-sectional analysis

AU - Yu, Fang

AU - Chen, Yan

AU - Mathiason, Michelle A.

AU - Wan, Qiaoqin

AU - Lin, Feng V.

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Understanding the factors affecting activities of daily living (ADL) is important in Alzheimer's disease (AD), because decline in ADL contributes to many poor health outcomes. Existing studies often investigate the factors in isolation without a theoretical framework. The purpose of the present study was to provide preliminary results on how cognition, physical performance, and behavioral and psychological symptoms of dementia mediate the relationship of aerobic fitness and ADL in AD. A cross-sectional analysis was used (n = 28: average age 78 [8] years, education 16 (3) years, Mini-Mental State Examination scores 20 [4]). The results showed that aerobic fitness is not linked to ADL directly, and its association with ADL was mediated by physical performance and global cognition. Our findings provide preliminary support for aerobic fitness as a potential therapeutic target, as enhanced aerobic fitness could simultaneously modify other factors affecting ADL. Nurses are in a unique position for coordinating exercise safety assessment and prescription and educating older adults with AD about exercise participation.

AB - Understanding the factors affecting activities of daily living (ADL) is important in Alzheimer's disease (AD), because decline in ADL contributes to many poor health outcomes. Existing studies often investigate the factors in isolation without a theoretical framework. The purpose of the present study was to provide preliminary results on how cognition, physical performance, and behavioral and psychological symptoms of dementia mediate the relationship of aerobic fitness and ADL in AD. A cross-sectional analysis was used (n = 28: average age 78 [8] years, education 16 (3) years, Mini-Mental State Examination scores 20 [4]). The results showed that aerobic fitness is not linked to ADL directly, and its association with ADL was mediated by physical performance and global cognition. Our findings provide preliminary support for aerobic fitness as a potential therapeutic target, as enhanced aerobic fitness could simultaneously modify other factors affecting ADL. Nurses are in a unique position for coordinating exercise safety assessment and prescription and educating older adults with AD about exercise participation.

KW - Alzheimer's disease

KW - activities of daily living

KW - aerobic fitness

KW - cognition

KW - dementia

UR - http://www.scopus.com/inward/record.url?scp=85046550441&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85046550441&partnerID=8YFLogxK

U2 - 10.1111/nhs.12426

DO - 10.1111/nhs.12426

M3 - Article

VL - 21

SP - 14

EP - 20

JO - Nursing and Health Sciences

JF - Nursing and Health Sciences

SN - 1441-0745

IS - 1

ER -