Abstract
Background & aims While a recent meta-analysis of prospective studies reported that coffee consumption is associated with a lower risk of cardiovascular disease mortality, limited and inconsistent data are available on the relation of coffee intake with subclinical disease. Thus, the aim of the present study was to see the association of coffee consumption with the prevalence of atherosclerotic plaque in the coronary arteries in NHLBI Family Heart Study. Methods In a cross-sectional design, we studied 1929 participants of the NHLBI Family Heart Study without known coronary heart disease. Coffee consumption was assessed by a semi-quantitative food frequency questionnaire and coronary-artery calcium (CAC) was measured by cardiac computed tomography. We defined prevalent CAC as an Agatston score of ≥100 and used generalized estimating equations to calculate prevalence ratios of CAC as well as a sensitivity analysis at a range of cutpoints for CAC. Results Mean age was 56.7 years and 59% of the study subjects were female. In adjusted analysis for age, sex, BMI, smoking, alcohol, physical activity, field center, and energy intake, prevalence ratio (95% CI) for CAC was 1.0 (reference), 0.92 (0.57–1.49), 1.34 (0.86–2.08), 1.30 (0.84–2.02), and 0.99 (0.60–1.64) for coffee consumption of almost never, <1/day, 1/day, 2–3/day, and ≥4 cups/day, respectively. In a sensitivity analysis, there was no evidence of association between coffee consumption and prevalent CAC when CAC cut points of 0, 50, 150, 200, and 300 were used. Conclusions These data do not provide evidence for an association between coffee consumption and prevalent CAC in adult men and women.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 18-21 |
| Number of pages | 4 |
| Journal | Clinical Nutrition ESPEN |
| Volume | 17 |
| DOIs | |
| State | Published - Feb 1 2017 |
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Keywords
- Atherosclerosis
- Coffee consumption
- Coronary artery calcium
- Epidemiology
- Nutrition
Cite this
Coffee consumption and calcified atherosclerotic plaques in the coronary arteries : The NHLBI Family Heart Study. / Patel, Yash R.; Gadiraju, Taraka V.; Ellison, R. Curtis; Hunt, Steven C.; Carr, John Jeffrey; Heiss, Gerardo; Arnett, Donna K.; Pankow, Jim; Gaziano, J. Michael; Djoussé, Luc.
In: Clinical Nutrition ESPEN, Vol. 17, 01.02.2017, p. 18-21.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Coffee consumption and calcified atherosclerotic plaques in the coronary arteries
T2 - The NHLBI Family Heart Study
AU - Patel, Yash R.
AU - Gadiraju, Taraka V.
AU - Ellison, R. Curtis
AU - Hunt, Steven C.
AU - Carr, John Jeffrey
AU - Heiss, Gerardo
AU - Arnett, Donna K.
AU - Pankow, Jim
AU - Gaziano, J. Michael
AU - Djoussé, Luc
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Background & aims While a recent meta-analysis of prospective studies reported that coffee consumption is associated with a lower risk of cardiovascular disease mortality, limited and inconsistent data are available on the relation of coffee intake with subclinical disease. Thus, the aim of the present study was to see the association of coffee consumption with the prevalence of atherosclerotic plaque in the coronary arteries in NHLBI Family Heart Study. Methods In a cross-sectional design, we studied 1929 participants of the NHLBI Family Heart Study without known coronary heart disease. Coffee consumption was assessed by a semi-quantitative food frequency questionnaire and coronary-artery calcium (CAC) was measured by cardiac computed tomography. We defined prevalent CAC as an Agatston score of ≥100 and used generalized estimating equations to calculate prevalence ratios of CAC as well as a sensitivity analysis at a range of cutpoints for CAC. Results Mean age was 56.7 years and 59% of the study subjects were female. In adjusted analysis for age, sex, BMI, smoking, alcohol, physical activity, field center, and energy intake, prevalence ratio (95% CI) for CAC was 1.0 (reference), 0.92 (0.57–1.49), 1.34 (0.86–2.08), 1.30 (0.84–2.02), and 0.99 (0.60–1.64) for coffee consumption of almost never, <1/day, 1/day, 2–3/day, and ≥4 cups/day, respectively. In a sensitivity analysis, there was no evidence of association between coffee consumption and prevalent CAC when CAC cut points of 0, 50, 150, 200, and 300 were used. Conclusions These data do not provide evidence for an association between coffee consumption and prevalent CAC in adult men and women.
AB - Background & aims While a recent meta-analysis of prospective studies reported that coffee consumption is associated with a lower risk of cardiovascular disease mortality, limited and inconsistent data are available on the relation of coffee intake with subclinical disease. Thus, the aim of the present study was to see the association of coffee consumption with the prevalence of atherosclerotic plaque in the coronary arteries in NHLBI Family Heart Study. Methods In a cross-sectional design, we studied 1929 participants of the NHLBI Family Heart Study without known coronary heart disease. Coffee consumption was assessed by a semi-quantitative food frequency questionnaire and coronary-artery calcium (CAC) was measured by cardiac computed tomography. We defined prevalent CAC as an Agatston score of ≥100 and used generalized estimating equations to calculate prevalence ratios of CAC as well as a sensitivity analysis at a range of cutpoints for CAC. Results Mean age was 56.7 years and 59% of the study subjects were female. In adjusted analysis for age, sex, BMI, smoking, alcohol, physical activity, field center, and energy intake, prevalence ratio (95% CI) for CAC was 1.0 (reference), 0.92 (0.57–1.49), 1.34 (0.86–2.08), 1.30 (0.84–2.02), and 0.99 (0.60–1.64) for coffee consumption of almost never, <1/day, 1/day, 2–3/day, and ≥4 cups/day, respectively. In a sensitivity analysis, there was no evidence of association between coffee consumption and prevalent CAC when CAC cut points of 0, 50, 150, 200, and 300 were used. Conclusions These data do not provide evidence for an association between coffee consumption and prevalent CAC in adult men and women.
KW - Atherosclerosis
KW - Coffee consumption
KW - Coronary artery calcium
KW - Epidemiology
KW - Nutrition
UR - http://www.scopus.com/inward/record.url?scp=85009473251&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85009473251&partnerID=8YFLogxK
U2 - 10.1016/j.clnesp.2016.12.003
DO - 10.1016/j.clnesp.2016.12.003
M3 - Article
VL - 17
SP - 18
EP - 21
JO - Clinical Nutrition ESPEN
JF - Clinical Nutrition ESPEN
SN - 2405-4577
ER -