Codiversification of gut microbiota with humans

Taichi A. Suzuki; J. Liam Fitzstevens; Victor T. Schmidt; Hagay Enav; Kelsey E. Huus; Mirabeau Mbong Ngwese; Anne Grießhammer; Anne Pfleiderer; Bayode R. Adegbite; Jeannot F. Zinsou; Meral Esen; Thirumalaisamy P. Velavan; Ayola A. Adegnika; Le Huu Song; Timothy D. Spector; Amanda L Muehlbauer; Nina Marchi; Hyena Kang; Lisa Maier; Ran Blekhman; Laure Ségurel; Gwang Pyo Ko; Nicholas D. Youngblut; Peter Kremsner; Ruth E. Ley

doi:10.1126/science.abm7759

Codiversification of gut microbiota with humans

Taichi A. Suzuki
, J. Liam Fitzstevens
, Victor T. Schmidt
, Hagay Enav
, Kelsey E. Huus
, Mirabeau Mbong Ngwese
, Anne Grießhammer
, Anne Pfleiderer
, Bayode R. Adegbite
, Jeannot F. Zinsou
, Meral Esen
, Thirumalaisamy P. Velavan
, Ayola A. Adegnika
, Le Huu Song
, Timothy D. Spector
, Amanda L Muehlbauer
, Nina Marchi
, Hyena Kang
, Lisa Maier
, Ran Blekhman

Laure Ségurel, Gwang Pyo Ko, Nicholas D. Youngblut, Peter Kremsner, Ruth E. Ley

Ecology, Evolution and Behavior

Research output: Contribution to journal › Article › peer-review

159 Scopus citations

Abstract

The gut microbiomes of human populations worldwide have many core microbial species in common. However, within a species, some strains can show remarkable population specificity. The question is whether such specificity arises from a shared evolutionary history (codiversification) between humans and their microbes. To test for codiversification of host and microbiota, we analyzed paired gut metagenomes and human genomes for 1225 individuals in Europe, Asia, and Africa, including mothers and their children. Between and within countries, a parallel evolutionary history was evident for humans and their gut microbes. Moreover, species displaying the strongest codiversification independently evolved traits characteristic of host dependency, including reduced genomes and oxygen and temperature sensitivity. These findings all point to the importance of understanding the potential role of population-specific microbial strains in microbiome-mediated disease phenotypes.

Original language	English (US)
Pages (from-to)	1328-1332
Number of pages	5
Journal	Science
Volume	377
Issue number	6612
DOIs	https://doi.org/10.1126/science.abm7759
State	Published - Sep 16 2022

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Copyright © 2022 The Authors.

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Suzuki, T. A., Fitzstevens, J. L., Schmidt, V. T., Enav, H., Huus, K. E., Mbong Ngwese, M., Grießhammer, A., Pfleiderer, A., Adegbite, B. R., Zinsou, J. F., Esen, M., Velavan, T. P., Adegnika, A. A., Song, L. H., Spector, T. D., Muehlbauer, A. L., Marchi, N., Kang, H., Maier, L., ... Ley, R. E. (2022). Codiversification of gut microbiota with humans. Science, 377(6612), 1328-1332. https://doi.org/10.1126/science.abm7759

Suzuki, TA, Fitzstevens, JL, Schmidt, VT, Enav, H, Huus, KE, Mbong Ngwese, M, Grießhammer, A, Pfleiderer, A, Adegbite, BR, Zinsou, JF, Esen, M, Velavan, TP, Adegnika, AA, Song, LH, Spector, TD, Muehlbauer, AL, Marchi, N, Kang, H, Maier, L, Blekhman, R, Ségurel, L, Ko, GP, Youngblut, ND, Kremsner, P & Ley, RE 2022, 'Codiversification of gut microbiota with humans', Science, vol. 377, no. 6612, pp. 1328-1332. https://doi.org/10.1126/science.abm7759

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title = "Codiversification of gut microbiota with humans",

abstract = "The gut microbiomes of human populations worldwide have many core microbial species in common. However, within a species, some strains can show remarkable population specificity. The question is whether such specificity arises from a shared evolutionary history (codiversification) between humans and their microbes. To test for codiversification of host and microbiota, we analyzed paired gut metagenomes and human genomes for 1225 individuals in Europe, Asia, and Africa, including mothers and their children. Between and within countries, a parallel evolutionary history was evident for humans and their gut microbes. Moreover, species displaying the strongest codiversification independently evolved traits characteristic of host dependency, including reduced genomes and oxygen and temperature sensitivity. These findings all point to the importance of understanding the potential role of population-specific microbial strains in microbiome-mediated disease phenotypes.",

author = "Suzuki, \{Taichi A.\} and Fitzstevens, \{J. Liam\} and Schmidt, \{Victor T.\} and Hagay Enav and Huus, \{Kelsey E.\} and \{Mbong Ngwese\}, Mirabeau and Anne Grie{\ss}hammer and Anne Pfleiderer and Adegbite, \{Bayode R.\} and Zinsou, \{Jeannot F.\} and Meral Esen and Velavan, \{Thirumalaisamy P.\} and Adegnika, \{Ayola A.\} and Song, \{Le Huu\} and Spector, \{Timothy D.\} and Muehlbauer, \{Amanda L\} and Nina Marchi and Hyena Kang and Lisa Maier and Ran Blekhman and Laure S{\'e}gurel and Ko, \{Gwang Pyo\} and Youngblut, \{Nicholas D.\} and Peter Kremsner and Ley, \{Ruth E.\}",

note = "Publisher Copyright: Copyright {\textcopyright} 2022 The Authors.",

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doi = "10.1126/science.abm7759",

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AU - Suzuki, Taichi A.

AU - Fitzstevens, J. Liam

AU - Schmidt, Victor T.

AU - Enav, Hagay

AU - Huus, Kelsey E.

AU - Mbong Ngwese, Mirabeau

AU - Grießhammer, Anne

AU - Pfleiderer, Anne

AU - Adegbite, Bayode R.

AU - Zinsou, Jeannot F.

AU - Esen, Meral

AU - Velavan, Thirumalaisamy P.

AU - Adegnika, Ayola A.

AU - Song, Le Huu

AU - Spector, Timothy D.

AU - Muehlbauer, Amanda L

AU - Marchi, Nina

AU - Kang, Hyena

AU - Maier, Lisa

AU - Blekhman, Ran

AU - Ségurel, Laure

AU - Ko, Gwang Pyo

AU - Youngblut, Nicholas D.

AU - Kremsner, Peter

AU - Ley, Ruth E.

PY - 2022/9/16

Y1 - 2022/9/16

N2 - The gut microbiomes of human populations worldwide have many core microbial species in common. However, within a species, some strains can show remarkable population specificity. The question is whether such specificity arises from a shared evolutionary history (codiversification) between humans and their microbes. To test for codiversification of host and microbiota, we analyzed paired gut metagenomes and human genomes for 1225 individuals in Europe, Asia, and Africa, including mothers and their children. Between and within countries, a parallel evolutionary history was evident for humans and their gut microbes. Moreover, species displaying the strongest codiversification independently evolved traits characteristic of host dependency, including reduced genomes and oxygen and temperature sensitivity. These findings all point to the importance of understanding the potential role of population-specific microbial strains in microbiome-mediated disease phenotypes.

AB - The gut microbiomes of human populations worldwide have many core microbial species in common. However, within a species, some strains can show remarkable population specificity. The question is whether such specificity arises from a shared evolutionary history (codiversification) between humans and their microbes. To test for codiversification of host and microbiota, we analyzed paired gut metagenomes and human genomes for 1225 individuals in Europe, Asia, and Africa, including mothers and their children. Between and within countries, a parallel evolutionary history was evident for humans and their gut microbes. Moreover, species displaying the strongest codiversification independently evolved traits characteristic of host dependency, including reduced genomes and oxygen and temperature sensitivity. These findings all point to the importance of understanding the potential role of population-specific microbial strains in microbiome-mediated disease phenotypes.

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VL - 377

SP - 1328

EP - 1332

JO - Science

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ER -

Codiversification of gut microbiota with humans

Abstract

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