Cochlospermum planchonii rhizome extract with hepatoprotective activity inhibits cytochrome P‐450 monooxygenases

Roseline Aliyu, Z. S.C. Okoye, W. Thomas Shier

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

An aqueous extract of Cochlospermum planchonii rhizomes prepared in the manner used by native medical practitioners in northern Nigeria to treat jaundice protects CCI4‐treated rats from liver damage measured as elevated serum levels of diagnostic enzymes. The extract inhibits cytochrome P‐450 monoxygenases aminopyrine‐N‐demethylase and aniline hydroxylase, suggesting a plausible hepatoprotective mechanism.

Original languageEnglish (US)
Pages (from-to)600-602
Number of pages3
JournalPhytotherapy Research
Volume9
Issue number8
DOIs
StatePublished - Dec 1995

Keywords

  • Cochlospermum planchonii
  • alanine aminotransferase
  • aspartate aminotransferase
  • cytochrome P‐450
  • hepatoprotective agent

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