Cochleotoxicity of otic drops in the chinchilla: Comparative study of Bestron and Cortisporin

K. Ikeda, T. Morizono, S. K. Juhn

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Bestron,® a new otic preparation containing cefmenoxime, was applied to the round window membrane of the chinchilla and the long-term cochleotoxicity was evaluated by means of electrocochleography. The thresholds of the compound action potential (CAP) in all frequency areas tested ranged within normal values. The input-output and -latency relationships of the CAP resulted in no significant deterioration of hearing. However, identical treatment with Cortisporin® resulted in elevated CAP threshold in the high frequency area and deterioration of the input-output and -latency of the GAP. These findings indicate that Bestron is noncochleotoxic as compared with Cortisporin and therefore may be used safely in the treatment of infected ears.

Original languageEnglish (US)
Pages (from-to)429-434
Number of pages6
JournalAmerican Journal of Otology
Volume12
Issue number6
StatePublished - 1991

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