Cochlear vascular changes in streptozotocin diabetes in chinchillas

C. A. Oliveira, C. Kruse, S. K. Juhn

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Abstract

Chinchillas were made diabetic by the i.p. injection of streptozotocin, and the cochlear blood vessels were studied using surface preparation techniques after 3, 6, and 12 mth of diabetes mellitus. The following findings were reported: a decrease of alkaline phosphatase activity in the walls of cochlear capillaries after 6 mth of established diabetes, a generalized involvement of the cochlear microcirculation as evidenced by the decrease in alkaline phosphatase activity and by narrowing and irregularities of the capillary lumen, and areas of complete capillary closure in the stria vascularis of the basal turn after 6 and 12 mth of established diabetes.

Original languageEnglish (US)
Pages (from-to)ORL-443-451
JournalTransactions of the American Academy of Ophthalmology and Otolaryngology
Volume84
Issue number2
StatePublished - Dec 1 1977

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