TY - JOUR
T1 - Cochlear changes in presbycusis with tinnitus
AU - Terao, Kyoichi
AU - Cureoglu, Sebahattin
AU - Schachern, Patricia A.
AU - Morita, Norimasa
AU - Nomiya, Shigenobu
AU - Deroee, Armin F.
AU - Doi, Katsumi
AU - Mori, Kazunori
AU - Murata, Kiyotaka
AU - Paparella, Michael M.
N1 - Funding Information:
Funding/support: This study was supported by the International Hearing Foundation, the Starkey Foundation, and the Society for Promotion of International Oto-Rhino-Laryngology.
PY - 2011/5
Y1 - 2011/5
N2 - Objectives: The pathophysiology of tinnitus is obscure and its treatment is therefore elusive. Significant progress in this field can only be achieved by determining the mechanisms of tinnitus generation, and thus, histopathologic findings of the cochlea in presbycusis with tinnitus become crucial. We revealed the histopathologic findings of the cochlea in subjects with presbycusis and tinnitus. Material and methods: The subjects were divided into 2 groups, presbycusis with tinnitus (tinnitus) group and presbycusis without tinnitus (control) group, with each group comprising 8 temporal bones from 8 subjects. We quantitatively analyzed the number of spiral ganglion cells, loss of cochlear inner and outer hair cells, and areas of the stria vascularis and spiral ligament. Results: There was a significantly greater loss of outer hair cells in the tinnitus group compared with the control group in the basal and upper middle turns. The stria vascularis was more atrophic in the tinnitus group compared with the control group in the basal turn. Conclusions: Tinnitus is more common in patients with presbycusis who have more severe degeneration of outer hair cells and stria vascularis.
AB - Objectives: The pathophysiology of tinnitus is obscure and its treatment is therefore elusive. Significant progress in this field can only be achieved by determining the mechanisms of tinnitus generation, and thus, histopathologic findings of the cochlea in presbycusis with tinnitus become crucial. We revealed the histopathologic findings of the cochlea in subjects with presbycusis and tinnitus. Material and methods: The subjects were divided into 2 groups, presbycusis with tinnitus (tinnitus) group and presbycusis without tinnitus (control) group, with each group comprising 8 temporal bones from 8 subjects. We quantitatively analyzed the number of spiral ganglion cells, loss of cochlear inner and outer hair cells, and areas of the stria vascularis and spiral ligament. Results: There was a significantly greater loss of outer hair cells in the tinnitus group compared with the control group in the basal and upper middle turns. The stria vascularis was more atrophic in the tinnitus group compared with the control group in the basal turn. Conclusions: Tinnitus is more common in patients with presbycusis who have more severe degeneration of outer hair cells and stria vascularis.
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U2 - 10.1016/j.amjoto.2010.02.001
DO - 10.1016/j.amjoto.2010.02.001
M3 - Article
C2 - 20434804
AN - SCOPUS:79955521248
SN - 0196-0709
VL - 32
SP - 215
EP - 220
JO - American Journal of Otolaryngology - Head and Neck Medicine and Surgery
JF - American Journal of Otolaryngology - Head and Neck Medicine and Surgery
IS - 3
ER -