Cocaine self-administration and reinstatement in female rats selectively bred for high and low voluntary running

J. R. Smethells, N. E. Zlebnik, D. K. Miller, M. J. Will, F. Booth, Marilyn E Carroll

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background Previous research has found that rats behaviorally screened for high (vs. low) wheel running were more vulnerable to cocaine abuse. To assess the extent to which a genetic component is involved in this drug-abuse vulnerability, rats selectively bred for high or low voluntary running (HVR or LVR, respectively) were examined for differences in cocaine seeking in the present study. Methods Female rats were trained to lever press for food and then were assessed for differences in acquisition of cocaine (0.4 mg/kg; i.v.) self-administration across 10 sessions. Once acquired, rats self-administered cocaine for a 14-day maintenance phase, followed by a 14-day extinction phase when cocaine was no longer available. Subsequently, reinstatement of cocaine seeking was examined with priming injections of cocaine (5, 10 & 15 mg/kg), caffeine (30 mg/kg), yohimbine (2.5 mg/kg) and cocaine-paired cues. Results A greater percentage of LVR rats met the acquisition criteria for cocaine self-administration and in fewer sessions than HVR rats. No differences in responding for cocaine were observed between phenotypes during maintenance. However, during extinction LVR rats initially responded at higher rates and persisted in cocaine seeking for a greater number of sessions. No phenotype differences were observed following drug and cue-primed reinstatement of cocaine seeking. Conclusions In general, LVR rats were more sensitive to the reinforcing effects of cocaine than HVR rats during periods of transition into and out of cocaine self-administration. Thus, LVR rats sometimes showed a greater vulnerability cocaine seeking than HVR rats.

Original languageEnglish (US)
Pages (from-to)163-168
Number of pages6
JournalDrug and alcohol dependence
Volume167
DOIs
StatePublished - Jun 7 2016

Fingerprint

Self Administration
Cocaine
Running
Rats
Cues
Maintenance
Phenotype
Cocaine-Related Disorders
Yohimbine
Caffeine
Substance-Related Disorders
Pharmaceutical Preparations

Keywords

  • Acquisition
  • Cocaine self-administration
  • Extinction
  • Phenotype
  • Rats
  • Wheel running

Cite this

Cocaine self-administration and reinstatement in female rats selectively bred for high and low voluntary running. / Smethells, J. R.; Zlebnik, N. E.; Miller, D. K.; Will, M. J.; Booth, F.; Carroll, Marilyn E.

In: Drug and alcohol dependence, Vol. 167, 07.06.2016, p. 163-168.

Research output: Contribution to journalArticle

Smethells, J. R. ; Zlebnik, N. E. ; Miller, D. K. ; Will, M. J. ; Booth, F. ; Carroll, Marilyn E. / Cocaine self-administration and reinstatement in female rats selectively bred for high and low voluntary running. In: Drug and alcohol dependence. 2016 ; Vol. 167. pp. 163-168.
@article{bf1b48efc0534a2d858e6b5b5d64904e,
title = "Cocaine self-administration and reinstatement in female rats selectively bred for high and low voluntary running",
abstract = "Background Previous research has found that rats behaviorally screened for high (vs. low) wheel running were more vulnerable to cocaine abuse. To assess the extent to which a genetic component is involved in this drug-abuse vulnerability, rats selectively bred for high or low voluntary running (HVR or LVR, respectively) were examined for differences in cocaine seeking in the present study. Methods Female rats were trained to lever press for food and then were assessed for differences in acquisition of cocaine (0.4 mg/kg; i.v.) self-administration across 10 sessions. Once acquired, rats self-administered cocaine for a 14-day maintenance phase, followed by a 14-day extinction phase when cocaine was no longer available. Subsequently, reinstatement of cocaine seeking was examined with priming injections of cocaine (5, 10 & 15 mg/kg), caffeine (30 mg/kg), yohimbine (2.5 mg/kg) and cocaine-paired cues. Results A greater percentage of LVR rats met the acquisition criteria for cocaine self-administration and in fewer sessions than HVR rats. No differences in responding for cocaine were observed between phenotypes during maintenance. However, during extinction LVR rats initially responded at higher rates and persisted in cocaine seeking for a greater number of sessions. No phenotype differences were observed following drug and cue-primed reinstatement of cocaine seeking. Conclusions In general, LVR rats were more sensitive to the reinforcing effects of cocaine than HVR rats during periods of transition into and out of cocaine self-administration. Thus, LVR rats sometimes showed a greater vulnerability cocaine seeking than HVR rats.",
keywords = "Acquisition, Cocaine self-administration, Extinction, Phenotype, Rats, Wheel running",
author = "Smethells, {J. R.} and Zlebnik, {N. E.} and Miller, {D. K.} and Will, {M. J.} and F. Booth and Carroll, {Marilyn E}",
year = "2016",
month = "6",
day = "7",
doi = "10.1016/j.drugalcdep.2016.08.020",
language = "English (US)",
volume = "167",
pages = "163--168",
journal = "Drug and Alcohol Dependence",
issn = "0376-8716",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Cocaine self-administration and reinstatement in female rats selectively bred for high and low voluntary running

AU - Smethells, J. R.

AU - Zlebnik, N. E.

AU - Miller, D. K.

AU - Will, M. J.

AU - Booth, F.

AU - Carroll, Marilyn E

PY - 2016/6/7

Y1 - 2016/6/7

N2 - Background Previous research has found that rats behaviorally screened for high (vs. low) wheel running were more vulnerable to cocaine abuse. To assess the extent to which a genetic component is involved in this drug-abuse vulnerability, rats selectively bred for high or low voluntary running (HVR or LVR, respectively) were examined for differences in cocaine seeking in the present study. Methods Female rats were trained to lever press for food and then were assessed for differences in acquisition of cocaine (0.4 mg/kg; i.v.) self-administration across 10 sessions. Once acquired, rats self-administered cocaine for a 14-day maintenance phase, followed by a 14-day extinction phase when cocaine was no longer available. Subsequently, reinstatement of cocaine seeking was examined with priming injections of cocaine (5, 10 & 15 mg/kg), caffeine (30 mg/kg), yohimbine (2.5 mg/kg) and cocaine-paired cues. Results A greater percentage of LVR rats met the acquisition criteria for cocaine self-administration and in fewer sessions than HVR rats. No differences in responding for cocaine were observed between phenotypes during maintenance. However, during extinction LVR rats initially responded at higher rates and persisted in cocaine seeking for a greater number of sessions. No phenotype differences were observed following drug and cue-primed reinstatement of cocaine seeking. Conclusions In general, LVR rats were more sensitive to the reinforcing effects of cocaine than HVR rats during periods of transition into and out of cocaine self-administration. Thus, LVR rats sometimes showed a greater vulnerability cocaine seeking than HVR rats.

AB - Background Previous research has found that rats behaviorally screened for high (vs. low) wheel running were more vulnerable to cocaine abuse. To assess the extent to which a genetic component is involved in this drug-abuse vulnerability, rats selectively bred for high or low voluntary running (HVR or LVR, respectively) were examined for differences in cocaine seeking in the present study. Methods Female rats were trained to lever press for food and then were assessed for differences in acquisition of cocaine (0.4 mg/kg; i.v.) self-administration across 10 sessions. Once acquired, rats self-administered cocaine for a 14-day maintenance phase, followed by a 14-day extinction phase when cocaine was no longer available. Subsequently, reinstatement of cocaine seeking was examined with priming injections of cocaine (5, 10 & 15 mg/kg), caffeine (30 mg/kg), yohimbine (2.5 mg/kg) and cocaine-paired cues. Results A greater percentage of LVR rats met the acquisition criteria for cocaine self-administration and in fewer sessions than HVR rats. No differences in responding for cocaine were observed between phenotypes during maintenance. However, during extinction LVR rats initially responded at higher rates and persisted in cocaine seeking for a greater number of sessions. No phenotype differences were observed following drug and cue-primed reinstatement of cocaine seeking. Conclusions In general, LVR rats were more sensitive to the reinforcing effects of cocaine than HVR rats during periods of transition into and out of cocaine self-administration. Thus, LVR rats sometimes showed a greater vulnerability cocaine seeking than HVR rats.

KW - Acquisition

KW - Cocaine self-administration

KW - Extinction

KW - Phenotype

KW - Rats

KW - Wheel running

UR - http://www.scopus.com/inward/record.url?scp=84994316134&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84994316134&partnerID=8YFLogxK

U2 - 10.1016/j.drugalcdep.2016.08.020

DO - 10.1016/j.drugalcdep.2016.08.020

M3 - Article

C2 - 27567437

AN - SCOPUS:84994316134

VL - 167

SP - 163

EP - 168

JO - Drug and Alcohol Dependence

JF - Drug and Alcohol Dependence

SN - 0376-8716

ER -