Cocaine place preference is blocked by the δ-opioid receptor antagonist, naltrindole

Kent Menkens; Edward J. Bilsky; Kenneth D. Wild; Philip S. Portoghese; Larry D. Reid; Frank Porreca

doi:10.1016/0014-2999(92)90319-Y

Cocaine place preference is blocked by the δ-opioid receptor antagonist, naltrindole

Kent Menkens, Edward J. Bilsky, Kenneth D. Wild, Philip S. Portoghese, Larry D. Reid, Frank Porreca

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

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Abstract

Naltrindole, a selective δ-opioid receptor antagonist, was evaluated for its potential to block the reinforcing properties of cocaine using a conditioned place pairing paradigm in Lewis rats. Cocaine HCl (15 mg/kg s.c.) produced a strong place preference which was significantly blocked in animals pretreated with naltrindole (3 mg/kg i.p.); naltrindole alone showed no reinforcing or aversive effects. The results suggest a novel approach for the treatment of cocaine abuse in man.

Original language	English (US)
Pages (from-to)	345-346
Number of pages	2
Journal	European Journal of Pharmacology
Volume	219
Issue number	2
DOIs	https://doi.org/10.1016/0014-2999(92)90319-Y
State	Published - Aug 25 1992

Keywords

Cocaine
Naltrindole
Place preference

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0014-2999(92)90319-Y

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title = "Cocaine place preference is blocked by the δ-opioid receptor antagonist, naltrindole",

abstract = "Naltrindole, a selective δ-opioid receptor antagonist, was evaluated for its potential to block the reinforcing properties of cocaine using a conditioned place pairing paradigm in Lewis rats. Cocaine HCl (15 mg/kg s.c.) produced a strong place preference which was significantly blocked in animals pretreated with naltrindole (3 mg/kg i.p.); naltrindole alone showed no reinforcing or aversive effects. The results suggest a novel approach for the treatment of cocaine abuse in man.",

keywords = "Cocaine, Naltrindole, Place preference",

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year = "1992",

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T1 - Cocaine place preference is blocked by the δ-opioid receptor antagonist, naltrindole

AU - Menkens, Kent

AU - Bilsky, Edward J.

AU - Wild, Kenneth D.

AU - Portoghese, Philip S.

AU - Reid, Larry D.

AU - Porreca, Frank

PY - 1992/8/25

Y1 - 1992/8/25

N2 - Naltrindole, a selective δ-opioid receptor antagonist, was evaluated for its potential to block the reinforcing properties of cocaine using a conditioned place pairing paradigm in Lewis rats. Cocaine HCl (15 mg/kg s.c.) produced a strong place preference which was significantly blocked in animals pretreated with naltrindole (3 mg/kg i.p.); naltrindole alone showed no reinforcing or aversive effects. The results suggest a novel approach for the treatment of cocaine abuse in man.

AB - Naltrindole, a selective δ-opioid receptor antagonist, was evaluated for its potential to block the reinforcing properties of cocaine using a conditioned place pairing paradigm in Lewis rats. Cocaine HCl (15 mg/kg s.c.) produced a strong place preference which was significantly blocked in animals pretreated with naltrindole (3 mg/kg i.p.); naltrindole alone showed no reinforcing or aversive effects. The results suggest a novel approach for the treatment of cocaine abuse in man.

KW - Cocaine

KW - Naltrindole

KW - Place preference

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DO - 10.1016/0014-2999(92)90319-Y

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AN - SCOPUS:0026782606

SN - 0014-2999

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JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 2

ER -

Cocaine place preference is blocked by the δ-opioid receptor antagonist, naltrindole

Abstract

Keywords

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