Cocaine dependence with and without comorbid depression: A comparison of patient characteristics

Joy M. Schmitz, Angela L. Stotts, Patricia M. Averill, Jennifer M. Rothfleisch, Steven E. Bailley, Shelly L. Sayre, John Grabowski

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


This study compared depressed cocaine dependent patients (CD, N = 50) with patients who were cocaine dependent only (CO, N = 101) on pre-treatment psychiatric symptomatology, substance use, and psychosocial functioning. Results indicated that the CD group had more overall distress and poorer psychiatric functioning than the CO group. CD individuals scored higher on all subscales of the SCL-90-R, had a higher prevalence of antisocial personality disorder, reported higher craving for cocaine, lower self- efficacy to refrain from drug use, and lower perceived social support. These findings support the need for more intensive treatment approaches for dually- diagnosed patients.

Original languageEnglish (US)
Pages (from-to)189-198
Number of pages10
JournalDrug and alcohol dependence
Issue number2
StatePublished - Aug 1 2000
Externally publishedYes

Bibliographical note

Funding Information:
This research was supported by the NIDA grants DA-09262-04 and DA-DA08654, and the Department of Psychiatry, University of Texas-Houston. Portions of this work were presented at the 60th Annual Scientific Meeting of the College on Problems of Drug Dependence, Scottsdale, AZ, June, 1998. We thank Amanda Schwebel, Kelli Drenner, Paula McCleary, and Albert Munn for their assistance on the project.


  • Cocaine dependence
  • Drug abuse
  • Dual-diagnosis
  • Major depression
  • Substance abuse comorbidity


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