Abstract
An aerobic cobalt-catalyzed oxidative cyclization of 2-aminophenols and isonitriles is reported. These additive-free conditions furnish a variety of substituted 2-aminobenzoxazoles in moderate to excellent yields. A series of control experiments and spectroscopic studies point to the importance of 2-aminophenol coordination in enabling the aerobic oxidation of cobalt(II).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4510-4514 |
| Number of pages | 5 |
| Journal | Organic Letters |
| Volume | 21 |
| Issue number | 12 |
| DOIs | |
| State | Published - Jun 21 2019 |
| Externally published | Yes |
Bibliographical note
Funding Information:We are grateful to West Virginia University and ACS PRF (56083-DNI3) for financial support of this work. NMR spectroscopy facilities were partially supported by the NSF (CHE-1228336).
Publisher Copyright:
© 2019 American Chemical Society.