Abstract
A ligand- and additive-free aerobic cobalt-catalyzed synthesis of 2-aminobenzimidazoles from 2-aminoanilines was developed. A variety of aminoanilines and isonitriles undergo efficient coupling to furnish substituted 2-aminobenzimidazoles in moderate to excellent yields. This protocol enables efficient access to the unsubstituted 2-aminobenzimidazoles.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1297-1301 |
| Number of pages | 5 |
| Journal | ChemCatChem |
| Volume | 12 |
| Issue number | 5 |
| DOIs | |
| State | Published - Mar 6 2020 |
| Externally published | Yes |
Bibliographical note
Funding Information:We are grateful to West Virginia University and ACS PRF (56083-DNI3) for financial support of this work. NMR spectroscopy facilities were partially supported by the NSF (CHE-1228336).
Publisher Copyright:
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Keywords
- cyclization
- homogeneous catalysis
- nitrogen heterocycles
- oxidation
- synthetic methods
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