Cobalt-Catalyzed Aerobic Oxidative Cyclization of 2-Aminoanilines with Isonitriles: Facile Access to 2-Aminobenzimidazoles

Jiaqi Liu; Sarah Morgan; Jessica M. Hoover

doi:10.1002/cctc.201902011

Cobalt-Catalyzed Aerobic Oxidative Cyclization of 2-Aminoanilines with Isonitriles: Facile Access to 2-Aminobenzimidazoles

Jiaqi Liu, Sarah Morgan, Jessica M. Hoover

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A ligand- and additive-free aerobic cobalt-catalyzed synthesis of 2-aminobenzimidazoles from 2-aminoanilines was developed. A variety of aminoanilines and isonitriles undergo efficient coupling to furnish substituted 2-aminobenzimidazoles in moderate to excellent yields. This protocol enables efficient access to the unsubstituted 2-aminobenzimidazoles.

Original language	English (US)
Pages (from-to)	1297-1301
Number of pages	5
Journal	ChemCatChem
Volume	12
Issue number	5
DOIs	https://doi.org/10.1002/cctc.201902011
State	Published - Mar 6 2020
Externally published	Yes

Bibliographical note

Funding Information:
We are grateful to West Virginia University and ACS PRF (56083-DNI3) for financial support of this work. NMR spectroscopy facilities were partially supported by the NSF (CHE-1228336).

Publisher Copyright:
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

cyclization
homogeneous catalysis
nitrogen heterocycles
oxidation
synthetic methods

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10.1002/cctc.201902011

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title = "Cobalt-Catalyzed Aerobic Oxidative Cyclization of 2-Aminoanilines with Isonitriles: Facile Access to 2-Aminobenzimidazoles",

abstract = "A ligand- and additive-free aerobic cobalt-catalyzed synthesis of 2-aminobenzimidazoles from 2-aminoanilines was developed. A variety of aminoanilines and isonitriles undergo efficient coupling to furnish substituted 2-aminobenzimidazoles in moderate to excellent yields. This protocol enables efficient access to the unsubstituted 2-aminobenzimidazoles.",

keywords = "cyclization, homogeneous catalysis, nitrogen heterocycles, oxidation, synthetic methods",

author = "Jiaqi Liu and Sarah Morgan and Hoover, {Jessica M.}",

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T2 - Facile Access to 2-Aminobenzimidazoles

AU - Liu, Jiaqi

AU - Morgan, Sarah

AU - Hoover, Jessica M.

N1 - Funding Information: We are grateful to West Virginia University and ACS PRF (56083-DNI3) for financial support of this work. NMR spectroscopy facilities were partially supported by the NSF (CHE-1228336). Publisher Copyright: © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

PY - 2020/3/6

Y1 - 2020/3/6

N2 - A ligand- and additive-free aerobic cobalt-catalyzed synthesis of 2-aminobenzimidazoles from 2-aminoanilines was developed. A variety of aminoanilines and isonitriles undergo efficient coupling to furnish substituted 2-aminobenzimidazoles in moderate to excellent yields. This protocol enables efficient access to the unsubstituted 2-aminobenzimidazoles.

AB - A ligand- and additive-free aerobic cobalt-catalyzed synthesis of 2-aminobenzimidazoles from 2-aminoanilines was developed. A variety of aminoanilines and isonitriles undergo efficient coupling to furnish substituted 2-aminobenzimidazoles in moderate to excellent yields. This protocol enables efficient access to the unsubstituted 2-aminobenzimidazoles.

KW - cyclization

KW - homogeneous catalysis

KW - nitrogen heterocycles

KW - oxidation

KW - synthetic methods

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Cobalt-Catalyzed Aerobic Oxidative Cyclization of 2-Aminoanilines with Isonitriles: Facile Access to 2-Aminobenzimidazoles

Abstract

Bibliographical note

Keywords

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