Cobalt-Catalyzed Aerobic Oxidative Cyclization of 2-Aminoanilines with Isonitriles: Facile Access to 2-Aminobenzimidazoles

Jiaqi Liu, Sarah Morgan, Jessica M. Hoover

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

A ligand- and additive-free aerobic cobalt-catalyzed synthesis of 2-aminobenzimidazoles from 2-aminoanilines was developed. A variety of aminoanilines and isonitriles undergo efficient coupling to furnish substituted 2-aminobenzimidazoles in moderate to excellent yields. This protocol enables efficient access to the unsubstituted 2-aminobenzimidazoles.

Original languageEnglish (US)
Pages (from-to)1297-1301
Number of pages5
JournalChemCatChem
Volume12
Issue number5
DOIs
StatePublished - Mar 6 2020
Externally publishedYes

Bibliographical note

Funding Information:
We are grateful to West Virginia University and ACS PRF (56083-DNI3) for financial support of this work. NMR spectroscopy facilities were partially supported by the NSF (CHE-1228336).

Publisher Copyright:
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

  • cyclization
  • homogeneous catalysis
  • nitrogen heterocycles
  • oxidation
  • synthetic methods

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