Coats' disease and Turner's syndrome

J. Douglas Cameron, Myron Yanoff, William C. Frayer

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


A baby girl with a karyotype of 45 XO (Turner's syndrome) had leukokoria of the right eye, and, because of suspected retinoblastoma, the eye was enucleated. The eye showed the typical histologic findings of Coats' disease. Coats' disease and Turner's syndrome have not been reported previously as occurring together.

Original languageEnglish (US)
Pages (from-to)852-854
Number of pages3
JournalAmerican journal of ophthalmology
Issue number5
StatePublished - Nov 1974
Externally publishedYes

Bibliographical note

Funding Information:
A premature infant was born at approximately 32 weeks gestation of a 29-year-old mother, gravida 3, para 1, one abortion, 24 hours after premature rupture of the placental membranes. Labor and delivery were uneventful as was the prenatal course. Birthweight was 4 lbs., 7 oz. The five-minute Apgar score was 8. The child was small with an estimated gestational age of 36 to 37 weeks. Physical examination revealed high arched palate, shield-shaped chest with widely spaced nipples, phenotypic female genitalia with a large clitoris, micrognathia, and lymphedema of both feet. A buccal smear was chromatin negative and the karyotype performed at Children's Hospital of Philadelphia was found to be 45 XO. No supplemental oxygen was administered during the un- From Departments of Ophthalmology and Pathology and the Laboratory of Ophthalmic Pathology, Scheie Eye Institute and University of Pennsylvania Medical School, Philadelphia, Pennsylvania. This study was supported by National Institutes of Health training grant S-T01-EY-00079-02 from the National Eye Institute.


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