Coagulation factor abnormalities related to discordance between anti-factor Xa and activated partial thromboplastin time in patients supported with continuous-flow left ventricular assist devices

Sirtaz Adatya, Roy Sunny, Megan J. Fitzpatrick, Monica Colvin, Thenappan Thenappan, Ranjit John, Nicole Dodge Zantek, Marc Pritzker, Peter Eckman, Nir Uriel

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Background High levels of discordance between activated partial thromboplastin time (aPTT) and anti-factor Xa (anti-FXa) have been reported in patients with continuous-flow left ventricular assist devices (CF-LVADs). We sought to determine the biochemical basis for discordance by simultaneous measurement of coagulation factors with aPTT and anti-FXa. Methods Consecutive CF-LVAD patients admitted for intravenous unfractionated heparin (IV-UFH) therapy were studied. IV-UFH was monitored based on an anti-FXa. International normalized ratio (INR), aPTT, lactate dehydrogenase, and coagulation factors II, V, VII, VIII, IX, X, XI, and XII were measured simultaneously with anti-FXa. Results The discordance rate between anti-FXa and aPTT was 74.7% overall (568 of 760 samples from 62 patients). In samples in which coagulation factors were simultaneously measured, the discordance rate was 66% (49 of 74 samples from 52 patients). In patients with INR ≤ 1.0 the discordance level was 31.8% vs 82.7% with INR > 1.8. No difference was observed in the rate of discordance between samples with low vs normal vitamin K–dependent factors (65.9% vs 64.7%, p = 0.99). Low factor XII was found in 15%; of these, 90.9% exhibited anti-FXa/aPTT discordance. Low factor V was found in 8.2%, and all were discordant. Factor VIII was elevated in 97% of samples, and 65.7% were discordant. Conclusions In addition to the effects of warfarin administration on aPTT, the influence of other factors, such as low factor XII or V, may contribute to the discordance between aPTT values and anti-FXa. Coagulation factor levels may assist in individualization of anti-coagulation targets while patients implanted with CF-LVADs are on IV-UFH.

Original languageEnglish (US)
Pages (from-to)1311-1320
Number of pages10
JournalJournal of Heart and Lung Transplantation
Volume35
Issue number11
DOIs
StatePublished - Nov 1 2016

Bibliographical note

Funding Information:
N.D.Z. has a financial interest in Endo International PLC and has received research funding from Sekisui Diagnostics, Bayer HealthCare, and AstraZeneca. P.E. has received honoraria and is a consultant for St. Jude Medical. R.J. has received research grants from St. Jude Medical and HeartWare. N.U. is a consultant for Thoratec, HeartWare, and Abiomed and serves as the national principal investigator for the MOMENTUM 3 study with no financial benefits. None of the other authors has a financial relationship with a commercial entity that has an interest in the subject of the presented manuscript or other conflicts of interest to disclose.

Publisher Copyright:
© 2016 International Society for Heart and Lung Transplantation

Keywords

  • PTT
  • activated partial thromboplastic time
  • anti-coagulation
  • anti-factor Xa
  • bleeding
  • coagulation factors
  • device thrombosis
  • hemolysis
  • heparin
  • ventricular assist device
  • warfarin

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