CoAching CD8+ T cells for tumor immunotherapy—the pantothenate way

Ameeta Kelekar; Stephen C. Jameson

doi:10.1016/j.cmet.2021.11.009

CoAching CD8⁺ T cells for tumor immunotherapy—the pantothenate way

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The metabolic state of T cells strongly influences their effector function and anti-tumor efficacy. St. Paul et al. (2021) report that Tc22, a CD8⁺ T cell subset with potent anti-tumor activity, upregulates the pantothenate/coenzyme A (CoA) pathway and that treatment with CoA or pantothenate is sufficient to enhance tumor immunotherapy.

Original language	English (US)
Pages (from-to)	2305-2306
Number of pages	2
Journal	Cell Metabolism
Volume	33
Issue number	12
DOIs	https://doi.org/10.1016/j.cmet.2021.11.009
State	Published - Dec 7 2021

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Inc.

PubMed: MeSH publication types

Journal Article
Comment

Publisher link

10.1016/j.cmet.2021.11.009

Find It

Find It at U of M Libraries

Cite this

@article{8b02f72998704701aa4b8744f404ee1f,

title = "CoAching CD8+ T cells for tumor immunotherapy{\textemdash}the pantothenate way",

abstract = "The metabolic state of T cells strongly influences their effector function and anti-tumor efficacy. St. Paul et al. (2021) report that Tc22, a CD8+ T cell subset with potent anti-tumor activity, upregulates the pantothenate/coenzyme A (CoA) pathway and that treatment with CoA or pantothenate is sufficient to enhance tumor immunotherapy.",

author = "Ameeta Kelekar and Jameson, \{Stephen C.\}",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

year = "2021",

month = dec,

day = "7",

doi = "10.1016/j.cmet.2021.11.009",

language = "English (US)",

volume = "33",

pages = "2305--2306",

journal = "Cell Metabolism",

issn = "1550-4131",

publisher = "Cell Press",

number = "12",

}

TY - JOUR

T1 - CoAching CD8+ T cells for tumor immunotherapy—the pantothenate way

AU - Kelekar, Ameeta

AU - Jameson, Stephen C.

PY - 2021/12/7

Y1 - 2021/12/7

N2 - The metabolic state of T cells strongly influences their effector function and anti-tumor efficacy. St. Paul et al. (2021) report that Tc22, a CD8+ T cell subset with potent anti-tumor activity, upregulates the pantothenate/coenzyme A (CoA) pathway and that treatment with CoA or pantothenate is sufficient to enhance tumor immunotherapy.

AB - The metabolic state of T cells strongly influences their effector function and anti-tumor efficacy. St. Paul et al. (2021) report that Tc22, a CD8+ T cell subset with potent anti-tumor activity, upregulates the pantothenate/coenzyme A (CoA) pathway and that treatment with CoA or pantothenate is sufficient to enhance tumor immunotherapy.

UR - https://www.scopus.com/pages/publications/85122496074

UR - https://www.scopus.com/pages/publications/85122496074#tab=citedBy

U2 - 10.1016/j.cmet.2021.11.009

DO - 10.1016/j.cmet.2021.11.009

M3 - Article

C2 - 34879235

AN - SCOPUS:85122496074

SN - 1550-4131

VL - 33

SP - 2305

EP - 2306

JO - Cell Metabolism

JF - Cell Metabolism

IS - 12

ER -