CoAching CD8+ T cells for tumor immunotherapy—the pantothenate way

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The metabolic state of T cells strongly influences their effector function and anti-tumor efficacy. St. Paul et al. (2021) report that Tc22, a CD8+ T cell subset with potent anti-tumor activity, upregulates the pantothenate/coenzyme A (CoA) pathway and that treatment with CoA or pantothenate is sufficient to enhance tumor immunotherapy.

Original languageEnglish (US)
Pages (from-to)2305-2306
Number of pages2
JournalCell Metabolism
Issue number12
StatePublished - Dec 7 2021

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© 2021 Elsevier Inc.

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