CoAching CD8+ T cells for tumor immunotherapy—the pantothenate way

Ameeta Kelekar; Stephen C. Jameson

doi:10.1016/j.cmet.2021.11.009

CoAching CD8⁺ T cells for tumor immunotherapy—the pantothenate way

Ameeta Kelekar, Stephen C. Jameson

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The metabolic state of T cells strongly influences their effector function and anti-tumor efficacy. St. Paul et al. (2021) report that Tc22, a CD8⁺ T cell subset with potent anti-tumor activity, upregulates the pantothenate/coenzyme A (CoA) pathway and that treatment with CoA or pantothenate is sufficient to enhance tumor immunotherapy.

Original language	English (US)
Pages (from-to)	2305-2306
Number of pages	2
Journal	Cell Metabolism
Volume	33
Issue number	12
DOIs	https://doi.org/10.1016/j.cmet.2021.11.009
State	Published - Dec 7 2021

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© 2021 Elsevier Inc.

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10.1016/j.cmet.2021.11.009

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abstract = "The metabolic state of T cells strongly influences their effector function and anti-tumor efficacy. St. Paul et al. (2021) report that Tc22, a CD8+ T cell subset with potent anti-tumor activity, upregulates the pantothenate/coenzyme A (CoA) pathway and that treatment with CoA or pantothenate is sufficient to enhance tumor immunotherapy.",

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