Co-Stimulatory functions of antigen-presenting cells

Julia G. Johnson, Marc Jenkins

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Antigen-presenting cells, in addition to presenting processed antigen, provide co-stimulatory signals that are necessary for stimulating maximal lymphokine production by CD4+ T cells. For interleukin 2 (IL-2) - producing CD4+ T cells, the B7 molecule provides an important co-stimulatory signal through interaction with its ligand on the T-cell surface, CD28. Populations of antigen-presenting cells that express high levels of B7 (e.g., dendritic cells) are much more potent stimulators of T-cell activation than cells that fail to express B7 (e.g., resting B cells). An increase in B7 expression could therefore explain the increased accessory function gained by Langerhans cells as they leave the skin and migrate to the draining lymph node. J Invest Dermatol 99: 62S- 65S, 1992.

Original languageEnglish (US)
Pages (from-to)62-65
Number of pages4
JournalJournal of Investigative Dermatology
Volume99
Issue number5
DOIs
StatePublished - Nov 1992

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