Co-expression of p53 by epithelial and stromal elements in carcinosarcoma of the female genital tract: An immunohistochemical study of 19 cases

S. A. Szukala, J. R. Marks, J. L. Burchette, A. A. Elbendary, Hannah R Krigman

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37 Scopus citations

Abstract

Carcinosarcoma is an aggressive neoplasm of the female genital tract, which comprises 1-2% of malignancies of the uterine corpus. Because of the broad range of differentiation exhibited by these tumors, the precise nature of the relationship between epithelial and stromal components in this unique tumor remain unclear. Previous studies have demonstrated that mutation and consequent overexpression of the tumor suppressor gene p53 occurs frequently in carcinosarcoma and is conserved from primary to metastatic sites. We examined p53 accumulation in formalin-fixed, paraffin-embedded archival sections in 19 cases previously shown to have mutations in the p53 gene and performed semi-quantitative analysis of the intensity of staining and relative density of positive cells and stromal and glandular elements. There was a high level of concordance of immunohistochemical staining for the p53 oncoprotein between glandular and stromal elements. These results further suggest a clonal origin for the diverse elements of carcinosarcoma.

Original languageEnglish (US)
Pages (from-to)131-136
Number of pages6
JournalInternational Journal of Gynecological Cancer
Volume9
Issue number2
DOIs
StatePublished - Jan 1 1999

Keywords

  • Female genital tract carcinosarcoma
  • Histogenesis
  • Malignant mixed Mullerian tumor
  • Tumor suppressor
  • p53

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