CNS involvement in the antisecretory action of [Met5]enkephalinamide on the rat intestine

David R. Brown; Richard J. Miller

doi:10.1016/0014-2999(83)90569-1

CNS involvement in the antisecretory action of [Met⁵]enkephalinamide on the rat intestine

David R. Brown
, Richard J. Miller

Veterinary and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

The effects of the stable enkephalin, [D-Ala², Met⁵]enkephalinamide (DAMA) were examined on basal and stimulated fluid accumulation in intestinal loops of anesthetized Wistar-Furth rats. DAMA (0.1-3.0 μg, i.c.v.) dose-dependently increased basal fluid absorption in the medial ileum and decreased jejunal and proximal ileal fluid secretion after 4 h cholera toxin (1 μg/loop) pretreatment. The antisecretory effects of DAMA were blocked by naltrexone (1 mg/kg s.c.). Thus, the antisecretory effects of opioids may be partially mediated at CNS sites.

Original language	English (US)
Pages (from-to)	441-444
Number of pages	4
Journal	European Journal of Pharmacology
Volume	90
Issue number	4
DOIs	https://doi.org/10.1016/0014-2999(83)90569-1
State	Published - Jun 17 1983

Bibliographical note

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

Keywords

Antidiarrheal activity
CNS site of action
Cholera toxin
Intestinal secretion
[D-Ala,Met]enkephalinamide

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0014-2999(83)90569-1

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title = "CNS involvement in the antisecretory action of [Met5]enkephalinamide on the rat intestine",

abstract = "The effects of the stable enkephalin, [D-Ala2, Met5]enkephalinamide (DAMA) were examined on basal and stimulated fluid accumulation in intestinal loops of anesthetized Wistar-Furth rats. DAMA (0.1-3.0 μg, i.c.v.) dose-dependently increased basal fluid absorption in the medial ileum and decreased jejunal and proximal ileal fluid secretion after 4 h cholera toxin (1 μg/loop) pretreatment. The antisecretory effects of DAMA were blocked by naltrexone (1 mg/kg s.c.). Thus, the antisecretory effects of opioids may be partially mediated at CNS sites.",

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N2 - The effects of the stable enkephalin, [D-Ala2, Met5]enkephalinamide (DAMA) were examined on basal and stimulated fluid accumulation in intestinal loops of anesthetized Wistar-Furth rats. DAMA (0.1-3.0 μg, i.c.v.) dose-dependently increased basal fluid absorption in the medial ileum and decreased jejunal and proximal ileal fluid secretion after 4 h cholera toxin (1 μg/loop) pretreatment. The antisecretory effects of DAMA were blocked by naltrexone (1 mg/kg s.c.). Thus, the antisecretory effects of opioids may be partially mediated at CNS sites.

AB - The effects of the stable enkephalin, [D-Ala2, Met5]enkephalinamide (DAMA) were examined on basal and stimulated fluid accumulation in intestinal loops of anesthetized Wistar-Furth rats. DAMA (0.1-3.0 μg, i.c.v.) dose-dependently increased basal fluid absorption in the medial ileum and decreased jejunal and proximal ileal fluid secretion after 4 h cholera toxin (1 μg/loop) pretreatment. The antisecretory effects of DAMA were blocked by naltrexone (1 mg/kg s.c.). Thus, the antisecretory effects of opioids may be partially mediated at CNS sites.

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KW - CNS site of action

KW - Cholera toxin

KW - Intestinal secretion

KW - [D-Ala,Met]enkephalinamide

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