CMV and HSV Pneumonia After Immunosuppressive Agents for Treatment of Cytokine Release Syndrome Due to Chimeric Antigen Receptor-modified T (CAR-T)-Cell Immunotherapy

Madeleine R. Heldman; Jimmy Ma; Jordan Gauthier; Riley A. O'Hara; Andrew J. Cowan; Leah M. Yoke; Lisa So; Elizabeth Gulleen; Elizabeth R. Duke; Catherine Liu; Cameron J. Turtle; Joshua A. Hill

doi:10.1097/CJI.0000000000000388

CMV and HSV Pneumonia After Immunosuppressive Agents for Treatment of Cytokine Release Syndrome Due to Chimeric Antigen Receptor-modified T (CAR-T)-Cell Immunotherapy

Madeleine R. Heldman
, Jimmy Ma
, Jordan Gauthier
, Riley A. O'Hara
, Andrew J. Cowan
, Leah M. Yoke
, Lisa So
, Elizabeth Gulleen
, Elizabeth R. Duke
, Catherine Liu
, Cameron J. Turtle
, Joshua A. Hill

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Pneumonia due to cytomegalovirus and herpes simplex virus-1 caused substantial morbidity after hematopoietic cell transplantation before the institution of preventative approaches. End-organ disease from herpesviruses is poorly described after chimeric antigen receptor-modified T-cell immunotherapy. We report 2 cases of cytomegalovirus pneumonia and 1 case of herpes simplex virus-1 gingivostomatitis, esophagitis, and pneumonia after chimeric antigen receptor-modified T-cell immunotherapy for the treatment of hematologic malignancies.

Original language	English (US)
Pages (from-to)	351-354
Number of pages	4
Journal	Journal of Immunotherapy
Volume	44
Issue number	9
DOIs	https://doi.org/10.1097/CJI.0000000000000388
State	Published - 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

chimeric antigen receptor-modified T (CAR-T)-cell therapy
cytomegalovirus (CMV)
herpes simplex virus-1 (HSV-1)
immunotherapy
pneumonia

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10.1097/CJI.0000000000000388

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Heldman, M. R., Ma, J., Gauthier, J., O'Hara, R. A., Cowan, A. J., Yoke, L. M., So, L., Gulleen, E., Duke, E. R., Liu, C., Turtle, C. J., & Hill, J. A. (2021). CMV and HSV Pneumonia After Immunosuppressive Agents for Treatment of Cytokine Release Syndrome Due to Chimeric Antigen Receptor-modified T (CAR-T)-Cell Immunotherapy. Journal of Immunotherapy, 44(9), 351-354. https://doi.org/10.1097/CJI.0000000000000388

Heldman, MR, Ma, J, Gauthier, J, O'Hara, RA, Cowan, AJ, Yoke, LM, So, L, Gulleen, E, Duke, ER, Liu, C, Turtle, CJ & Hill, JA 2021, 'CMV and HSV Pneumonia After Immunosuppressive Agents for Treatment of Cytokine Release Syndrome Due to Chimeric Antigen Receptor-modified T (CAR-T)-Cell Immunotherapy', Journal of Immunotherapy, vol. 44, no. 9, pp. 351-354. https://doi.org/10.1097/CJI.0000000000000388

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title = "CMV and HSV Pneumonia After Immunosuppressive Agents for Treatment of Cytokine Release Syndrome Due to Chimeric Antigen Receptor-modified T (CAR-T)-Cell Immunotherapy",

abstract = "Pneumonia due to cytomegalovirus and herpes simplex virus-1 caused substantial morbidity after hematopoietic cell transplantation before the institution of preventative approaches. End-organ disease from herpesviruses is poorly described after chimeric antigen receptor-modified T-cell immunotherapy. We report 2 cases of cytomegalovirus pneumonia and 1 case of herpes simplex virus-1 gingivostomatitis, esophagitis, and pneumonia after chimeric antigen receptor-modified T-cell immunotherapy for the treatment of hematologic malignancies.",

keywords = "chimeric antigen receptor-modified T (CAR-T)-cell therapy, cytomegalovirus (CMV), herpes simplex virus-1 (HSV-1), immunotherapy, pneumonia",

author = "Heldman, \{Madeleine R.\} and Jimmy Ma and Jordan Gauthier and O'Hara, \{Riley A.\} and Cowan, \{Andrew J.\} and Yoke, \{Leah M.\} and Lisa So and Elizabeth Gulleen and Duke, \{Elizabeth R.\} and Catherine Liu and Turtle, \{Cameron J.\} and Hill, \{Joshua A.\}",

note = "Publisher Copyright: Copyright {\textcopyright} 2021 The Author(s). Published by Wolters Kluwer Health, Inc.",

year = "2021",

doi = "10.1097/CJI.0000000000000388",

language = "English (US)",

volume = "44",

pages = "351--354",

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AU - Heldman, Madeleine R.

AU - Ma, Jimmy

AU - Gauthier, Jordan

AU - O'Hara, Riley A.

AU - Cowan, Andrew J.

AU - Yoke, Leah M.

AU - So, Lisa

AU - Gulleen, Elizabeth

AU - Duke, Elizabeth R.

AU - Liu, Catherine

AU - Turtle, Cameron J.

AU - Hill, Joshua A.

PY - 2021

Y1 - 2021

N2 - Pneumonia due to cytomegalovirus and herpes simplex virus-1 caused substantial morbidity after hematopoietic cell transplantation before the institution of preventative approaches. End-organ disease from herpesviruses is poorly described after chimeric antigen receptor-modified T-cell immunotherapy. We report 2 cases of cytomegalovirus pneumonia and 1 case of herpes simplex virus-1 gingivostomatitis, esophagitis, and pneumonia after chimeric antigen receptor-modified T-cell immunotherapy for the treatment of hematologic malignancies.

AB - Pneumonia due to cytomegalovirus and herpes simplex virus-1 caused substantial morbidity after hematopoietic cell transplantation before the institution of preventative approaches. End-organ disease from herpesviruses is poorly described after chimeric antigen receptor-modified T-cell immunotherapy. We report 2 cases of cytomegalovirus pneumonia and 1 case of herpes simplex virus-1 gingivostomatitis, esophagitis, and pneumonia after chimeric antigen receptor-modified T-cell immunotherapy for the treatment of hematologic malignancies.

KW - chimeric antigen receptor-modified T (CAR-T)-cell therapy

KW - cytomegalovirus (CMV)

KW - herpes simplex virus-1 (HSV-1)

KW - immunotherapy

KW - pneumonia

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AN - SCOPUS:85118283258

SN - 1524-9557

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JF - Journal of Immunotherapy

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CMV and HSV Pneumonia After Immunosuppressive Agents for Treatment of Cytokine Release Syndrome Due to Chimeric Antigen Receptor-modified T (CAR-T)-Cell Immunotherapy

Abstract

Bibliographical note

UN SDGs

Keywords

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