CMV and HSV Pneumonia After Immunosuppressive Agents for Treatment of Cytokine Release Syndrome Due to Chimeric Antigen Receptor-modified T (CAR-T)-Cell Immunotherapy

Madeleine R. Heldman; Jimmy Ma; Jordan Gauthier; Riley A. O'Hara; Andrew J. Cowan; Leah M. Yoke; Lisa So; Elizabeth Gulleen; Elizabeth R. Duke; Catherine Liu; Cameron J. Turtle; Joshua A. Hill

doi:10.1097/CJI.0000000000000388

CMV and HSV Pneumonia After Immunosuppressive Agents for Treatment of Cytokine Release Syndrome Due to Chimeric Antigen Receptor-modified T (CAR-T)-Cell Immunotherapy

Madeleine R. Heldman, Jimmy Ma, Jordan Gauthier, Riley A. O'Hara, Andrew J. Cowan, Leah M. Yoke, Lisa So, Elizabeth Gulleen, Elizabeth R. Duke, Catherine Liu, Cameron J. Turtle, Joshua A. Hill

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Pneumonia due to cytomegalovirus and herpes simplex virus-1 caused substantial morbidity after hematopoietic cell transplantation before the institution of preventative approaches. End-organ disease from herpesviruses is poorly described after chimeric antigen receptor-modified T-cell immunotherapy. We report 2 cases of cytomegalovirus pneumonia and 1 case of herpes simplex virus-1 gingivostomatitis, esophagitis, and pneumonia after chimeric antigen receptor-modified T-cell immunotherapy for the treatment of hematologic malignancies.

Original language	English (US)
Pages (from-to)	351-354
Number of pages	4
Journal	Journal of Immunotherapy
Volume	44
Issue number	9
DOIs	https://doi.org/10.1097/CJI.0000000000000388
State	Published - 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.

Keywords

chimeric antigen receptor-modified T (CAR-T)-cell therapy
cytomegalovirus (CMV)
herpes simplex virus-1 (HSV-1)
immunotherapy
pneumonia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/CJI.0000000000000388

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Heldman, M. R., Ma, J., Gauthier, J., O'Hara, R. A., Cowan, A. J., Yoke, L. M., So, L., Gulleen, E., Duke, E. R., Liu, C., Turtle, C. J., & Hill, J. A. (2021). CMV and HSV Pneumonia After Immunosuppressive Agents for Treatment of Cytokine Release Syndrome Due to Chimeric Antigen Receptor-modified T (CAR-T)-Cell Immunotherapy. Journal of Immunotherapy, 44(9), 351-354. https://doi.org/10.1097/CJI.0000000000000388

Heldman, MR, Ma, J, Gauthier, J, O'Hara, RA, Cowan, AJ, Yoke, LM, So, L, Gulleen, E, Duke, ER, Liu, C, Turtle, CJ & Hill, JA 2021, 'CMV and HSV Pneumonia After Immunosuppressive Agents for Treatment of Cytokine Release Syndrome Due to Chimeric Antigen Receptor-modified T (CAR-T)-Cell Immunotherapy', Journal of Immunotherapy, vol. 44, no. 9, pp. 351-354. https://doi.org/10.1097/CJI.0000000000000388

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abstract = "Pneumonia due to cytomegalovirus and herpes simplex virus-1 caused substantial morbidity after hematopoietic cell transplantation before the institution of preventative approaches. End-organ disease from herpesviruses is poorly described after chimeric antigen receptor-modified T-cell immunotherapy. We report 2 cases of cytomegalovirus pneumonia and 1 case of herpes simplex virus-1 gingivostomatitis, esophagitis, and pneumonia after chimeric antigen receptor-modified T-cell immunotherapy for the treatment of hematologic malignancies.",

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author = "Heldman, {Madeleine R.} and Jimmy Ma and Jordan Gauthier and O'Hara, {Riley A.} and Cowan, {Andrew J.} and Yoke, {Leah M.} and Lisa So and Elizabeth Gulleen and Duke, {Elizabeth R.} and Catherine Liu and Turtle, {Cameron J.} and Hill, {Joshua A.}",

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year = "2021",

doi = "10.1097/CJI.0000000000000388",

language = "English (US)",

volume = "44",

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AU - Heldman, Madeleine R.

AU - Ma, Jimmy

AU - Gauthier, Jordan

AU - O'Hara, Riley A.

AU - Cowan, Andrew J.

AU - Yoke, Leah M.

AU - So, Lisa

AU - Gulleen, Elizabeth

AU - Duke, Elizabeth R.

AU - Liu, Catherine

AU - Turtle, Cameron J.

AU - Hill, Joshua A.

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AB - Pneumonia due to cytomegalovirus and herpes simplex virus-1 caused substantial morbidity after hematopoietic cell transplantation before the institution of preventative approaches. End-organ disease from herpesviruses is poorly described after chimeric antigen receptor-modified T-cell immunotherapy. We report 2 cases of cytomegalovirus pneumonia and 1 case of herpes simplex virus-1 gingivostomatitis, esophagitis, and pneumonia after chimeric antigen receptor-modified T-cell immunotherapy for the treatment of hematologic malignancies.

KW - chimeric antigen receptor-modified T (CAR-T)-cell therapy

KW - cytomegalovirus (CMV)

KW - herpes simplex virus-1 (HSV-1)

KW - immunotherapy

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CMV and HSV Pneumonia After Immunosuppressive Agents for Treatment of Cytokine Release Syndrome Due to Chimeric Antigen Receptor-modified T (CAR-T)-Cell Immunotherapy

Abstract

Bibliographical note

Keywords

UN SDGs

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