Clusterin: Physiologic and pathophysiologic considerations

Mark E. Rosenberg, John Silkensen

Research output: Contribution to journalReview article

355 Scopus citations

Abstract

Clusterin is a heterodimeric glycoprotein produced by a wide array of tissues and found in most biologic fluids. A number of physiologic functions have been proposed for clusterin based on its distribution and in vitro properties. These include complement regulation, lipid transport, sperm maturation, initiation of apoptosis, endocrine secretion, membrane protection, and promotion of cell interactions. A prominent and defining feature of clusterin is its induction in such disease states as glomerulonephritis, polycystic kidney disease, renal tubular injury, neurodegenerative conditions including Alzheimer's disease, atherosclerosis, and myocardial infarction. The expression of clusterin in these states is puzzling, from the specific molecular species and cellular pathways eliciting such expression, to the roles subserved by clusterin once induced. This review will discuss these physiologic and pathophysiologic aspects of clusterin and speculate on its role in disease.

Original languageEnglish (US)
Pages (from-to)633-645
Number of pages13
JournalInternational Journal of Biochemistry and Cell Biology
Volume27
Issue number7
DOIs
StatePublished - Jul 1995

Keywords

  • Cell interactions
  • Clusterin
  • Complement
  • Injury
  • Lipoprotein

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