Closed-Loop Stimulation in Emotional Circuits for Neuro-Psychiatric Disorders

A. S. Widge, C. T. Moritz

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Psychiatric illnesses are a major public health challenge, with high burdens of disability and few effective treatments. Electrical stimulation of brain areas involved in emotion and cognition may help re-regulate dysfunctional limbic circuits. Despite promising early results, those open-loop therapies have not improved clinical outcomes. Closed-loop approaches may be more effective, as they can respond to fluctuations of brain and emotional state. We discuss the challenges in finding brain signals for closed-loop neurostimulation control and outline two possible routes to a solution. First, we describe how patients with existing deep brain stimulators can help us identify markers for feedback titration, by considering the unique case of a therapy that works for both depression and obsessive-compulsive disorder. Second, we outline a novel approach that adapts brain-computer interface technologies originally developed for paralysis. Both methods may be applicable to multiple diagnoses, and should be feasible with existing clinical hardware.

Original languageEnglish (US)
Title of host publicationClosed Loop Neuroscience
PublisherElsevier Inc.
Number of pages11
ISBN (Electronic)9780128026410
ISBN (Print)9780128024522
StatePublished - Sep 29 2016
Externally publishedYes


  • Brain-computer interface
  • Deep brain stimulation
  • Executive control
  • Neural prosthetics
  • Plasticity
  • Prefrontal cortex


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