Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy

Keyphrases

• Breast Tumor 100%
• Neoadjuvant 100%
• Clonal Heterogeneity 100%
• Clonal Replacement 100%
• HER2-targeted Therapy 100%
• Tumor 66%
• Genomic Changes 66%
• Mathematical Modeling 33%
• Statistical Methods 33%
• Computational Modeling 33%
• Heterogeneous Treatment Effects 33%
• Resistance Evolution 33%
• Whole Exome Sequencing 33%
• Primary Tumor 33%
• Clonal Evolution 33%
• Two-region 33%
• Tumor Heterogeneity 33%
• Surgical Specimen 33%
• Subclone 33%
• Heterogeneous Tumors 33%
• Tumor Samples 33%
• Primary Breast Tumor 33%
• Clonal Change 33%
• Multi-region Sampling 33%
• Treatment Modeling 33%
• Pretreatment Biopsy 33%

Medicine and Dentistry

• Breast Tumor 100%
• Targeted Therapy 100%
• Tumor 100%
• Neoplasm 33%
• Primary Tumor 33%
• Exome Sequencing 33%
• Biopsy Technique 33%
• Tumour Heterogeneity 33%

Biochemistry, Genetics and Molecular Biology

• Genomics 100%
• Targeted Therapy 100%
• Exome Sequencing 50%
• Clonal Evolution 50%