Clonal rearrangement for immunoglobulin and T-cell receptor genes in systemic Castleman's disease. Association with Epstein-Barr virus

C. A. Hanson, G. Frizzera, D. F. Patton, B. A. Peterson, K. McClain, K. J. Gajl-Peczalska, J. H. Kersey

Research output: Contribution to journalArticlepeer-review

117 Scopus citations

Abstract

Castleman's disease is a morphologically and clinically heterogeneous lymphoproliferative disorder. Both a localized benign variant and an aggressive form with systemic manifestations have been described. To investigate the differences between these variants of Castleman's disease, the authors analyzed lymph node DNA from 4 patients with the localized type and 4 with the systemic type of Castleman's disease for immunoglobulin and T-cell receptor gene rearrangements. The role of Epstein-Barr virus (EBV) and cytomegalovirus (CMV) was also studied by viral genomic DNA probes. They detected clonal rearrangements in 3 of the 4 patients with the systemic variant of Castleman's; no patients with localized disease had rearrangements. Copies of EBV genome were also detected in 2 of the 3 patients with clonal rearrangements. These results suggest that systemic Castleman's disease is a disorder distinct from the classical localized variant in that is may evolve into a clonal lymphoproliferation.

Original languageEnglish (US)
Pages (from-to)84-91
Number of pages8
JournalAmerican Journal of Pathology
Volume131
Issue number1
StatePublished - 1988

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