Clonal hematopoiesis of indeterminate potential in persons with HIV

Andreas D. Knudsen, Christian Winther Eskelund, Thomas Benfield, Yanan Zhao, Marco Gelpi, Lars Køber, Marius Trøseid, Klaus F. Kofoed, Sisse R. Ostrowski, Cavan Reilly, Álvaro H. Borges, Kirsten Grønbæk, Susanne D. Nielsen

Research output: Contribution to journalArticlepeer-review

Abstract

Background:Clonal hematopoiesis of indeterminate potential (CHIP) has been associated with older age, inflammation and with risk of coronary artery disease (CAD). We aimed to characterize the burden of CHIP, and to explore the association between CHIP, inflammatory markers, and CAD in older persons with HIV (PWH).Methods:From the Copenhagen Comorbidity in HIV Infection (COCOMO) study, we included 190 individuals older than 55 years of age. We defined CHIP as variant allele fraction at least 2%. CAD was categorized according to the most severe coronary artery lesion on coronary computed tomography (CT) angiography as no coronary atherosclerosis; any atherosclerosis defined as at least 1% stenosis and obstructive CAD defined as at least 50% stenosis.Results:In the entire population (median age 66 years, 87% men), we identified a total of 62 mutations distributed among 49 (26%) participants. The three most mutated genes were DNMT3A, TET2, and ASXL1, accounting for 49, 25, and 16% of mutations, respectively. Age and sex were the only variables associated with CHIP. IL-1β, IL-1Ra, IL-2, IL-6, IL-10, soluble CD14, soluble CD163 and TNF-α were not associated with CHIP, and CHIP was not associated with any atherosclerosis or with obstructive CAD in adjusted analyses.Conclusion:In older, well treated, Scandinavian PWH, more than one in four had at least one CHIP mutation. We did not find evidence of an association between CHIP and inflammatory markers or between CHIP and CAD. CHIP is an unlikely underlying mechanism to explain the association between inflammation and CAD in treated HIV disease.

Original languageEnglish (US)
Pages (from-to)487-495
Number of pages9
JournalAIDS
Volume38
Issue number4
DOIs
StatePublished - Mar 15 2024

Bibliographical note

Publisher Copyright:
© 2024 Lippincott Williams and Wilkins. All rights reserved.

Keywords

  • HIV
  • atherosclerosis
  • clonal haematopoiesis
  • clonal hematopoiesis of indeterminate potential
  • coronary artery disease
  • inflammation

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't

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