TY - JOUR
T1 - Clonal distribution and associated characteristics of Escherichia coli clinical and surveillance isolates from a military medical center
AU - Manges, Amee R.
AU - Mende, Katrin
AU - Murray, Clinton K.
AU - Johnston, Brian D.
AU - Sokurenko, Evgeni V.
AU - Tchesnokova, Veronika
AU - Johnson, James R.
N1 - Publisher Copyright:
© 2017
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Antimicrobial-resistant Escherichia coli are a concern for military health services. We studied 100 extended-spectrum beta-lactamase (ESBL)-producing and non-producing E. coli clinical and surveillance isolates from military personnel and civilians at Brooke Army Medical Center (2007–2011). Major E. coli lineages, most prominently ST10 (24%), ST131 (16%), and ST648 (8%), were distributed much as reported for other North American populations. ST131, represented mainly by its resistance-associated ST131-H30 clonal subset, was uniquely associated with a clinical origin, regardless of ESBL status. Thus, clonal background predicted resistance phenotype and clinical versus surveillance origin, and these findings could assist military clinicians and epidemiologists.
AB - Antimicrobial-resistant Escherichia coli are a concern for military health services. We studied 100 extended-spectrum beta-lactamase (ESBL)-producing and non-producing E. coli clinical and surveillance isolates from military personnel and civilians at Brooke Army Medical Center (2007–2011). Major E. coli lineages, most prominently ST10 (24%), ST131 (16%), and ST648 (8%), were distributed much as reported for other North American populations. ST131, represented mainly by its resistance-associated ST131-H30 clonal subset, was uniquely associated with a clinical origin, regardless of ESBL status. Thus, clonal background predicted resistance phenotype and clinical versus surveillance origin, and these findings could assist military clinicians and epidemiologists.
KW - Antimicrobial resistance
KW - Escherichia coli infections
KW - Extended-spectrum beta-lactamases
KW - Military medicine
KW - Molecular epidemiology
KW - Multilocus sequence typing
KW - ST131
KW - ST131-H30
KW - Veterans
KW - Virulence genes
UR - http://www.scopus.com/inward/record.url?scp=85013149715&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85013149715&partnerID=8YFLogxK
U2 - 10.1016/j.diagmicrobio.2017.01.007
DO - 10.1016/j.diagmicrobio.2017.01.007
M3 - Article
C2 - 28139277
AN - SCOPUS:85013149715
SN - 0732-8893
VL - 87
SP - 382
EP - 385
JO - Diagnostic Microbiology and Infectious Disease
JF - Diagnostic Microbiology and Infectious Disease
IS - 4
ER -
