Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation

D. R. DeSilva, K. B. Urdahl, Marc Jenkins

Research output: Contribution to journalArticlepeer-review

251 Scopus citations

Abstract

Murine Th1 clones that receive signals through their TCR in the absence of APC-derived co-stimulatory signals do not produce IL-2 and instead become anergic, i.e., they are subsequently unable to produce IL-2 in response to Ag and normal APC. The critical cellular event required to prevent the induction of this anergic state appears to be T cell proliferation. Anergy was induced when T cell clones were stimulated under conditions where both TCR occupancy and costimulatory signals were provided but where proliferation in response to the IL-2 produced was prevented. Once induced, anergy could be reversed if the T cells were allowed to undergo multiple rounds of cell division. These results show that anergy is induced as a consequence of TCR occupancy in the absence of cell division; this can be achieved either by limiting IL-2 production because of deficient provision of co-stimulatory signals or by preventing response to IL-2.

Original languageEnglish (US)
Pages (from-to)3261-3267
Number of pages7
JournalJournal of Immunology
Volume147
Issue number10
StatePublished - 1991

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