Clonal anergy blocks the response to IL-4, as well as the production of IL-2, in dual-producing T helper cell clones

Daniel L. Mueller, Lynda Chiodetti, Paul A. Bacon, Ronald H. Schwartz

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64 Scopus citations

Abstract

In this report we extend the in vitro clonal anergy model to examine the regulation of proliferation in T cells that secrete both IL-2 and IL-4. Newly cloned Ag-specific murine T cells are shown to depend on both IL-2 and IL-4 synthesis for maximal proliferation. Whereas IL-2 responsiveness is constitutive in these cells, IL-4 responsiveness develops only after Ag and APC stimulation. Remarkably, proliferation of these cells to Ag is sensitive to inhibition by clonal anergy, even though IL-4 synthesis remains inducible. Anergy in these cells is associated with an inability to respond to IL-4, in addition to the development of an IL-2 production defect. The results suggest that anergy induction may be capable of preventing the clonal expansion of autoreactive T cells producing both IL-2 and IL-4 in vivo.

Original languageEnglish (US)
Pages (from-to)4118-4125
Number of pages8
JournalJournal of Immunology
Volume147
Issue number12
StatePublished - 1991

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