TY - JOUR
T1 - Clomipramine treatment in neonatal rats alters the brain acetylcholinesterase activity in adulthood
AU - Mavanji, Vijayakumar
AU - Datta, Subimal
PY - 2002
Y1 - 2002
N2 - The enzyme, acetylcholinesterase, activity of the brain was measured in control and clomipramine-induced behaviorally depressed rats. Compared with control rats, the soluble form of acetylcholinesterase activity of the depressed rats was 31.8% higher in the hippocampus and 26.0% lower in the frontal cortex. However, the activity of soluble form of this enzyme was not significantly different in the hypothalamus, septum, and brainstem. These results suggest for the first time that the altered cholinergic activity in the specific areas of the brain may be involved in the behavioral depression observed in the rat model of human endogenous depression.
AB - The enzyme, acetylcholinesterase, activity of the brain was measured in control and clomipramine-induced behaviorally depressed rats. Compared with control rats, the soluble form of acetylcholinesterase activity of the depressed rats was 31.8% higher in the hippocampus and 26.0% lower in the frontal cortex. However, the activity of soluble form of this enzyme was not significantly different in the hypothalamus, septum, and brainstem. These results suggest for the first time that the altered cholinergic activity in the specific areas of the brain may be involved in the behavioral depression observed in the rat model of human endogenous depression.
KW - Acetylcholinesterase
KW - Animal model
KW - Clomipramine
KW - Endogenous depression
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U2 - 10.1016/S0304-3940(02)00725-5
DO - 10.1016/S0304-3940(02)00725-5
M3 - Article
C2 - 12213647
AN - SCOPUS:0037072536
SN - 0304-3940
VL - 330
SP - 119
EP - 121
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
M1 - 22701
ER -