Clofarabine desensitization: A case report: Leukemia research reports

Sarah M. Hayes, Justin A. Wasko, Erica Dahl Warlick

Research output: Contribution to journalArticle

Abstract

We describe a relapsed AML patient who had two prior severe reactions to clofarabine involving rigors, emesis, tachycardia, hypotension, and acute kidney injury. Given previous prolonged remission achieved with clofarabine and cytarabine therapy years prior, rechallenge was undertaken upon discovery of AML relapse. We designed a desensitization protocol performed with the first dose of clofarabine, leading to successful administration of the entire clofarabine/cytarabine treatment course. From this case we show promise for clofarabine rechallenge after prior hypersensitivity reactions in patients with few treatment options for relapsed AML.

Original languageEnglish (US)
Pages (from-to)14-16
Number of pages3
JournalLeukemia Research Reports
Volume7
DOIs
StatePublished - 2017

Keywords

  • Acute Myeloid Leukemia
  • Clofarabine
  • Desensitization

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