Clinipathological studies of a patients with adult T-cell leukemia and pseudogynecomasty

Paula Loureiro, Sarka O. Southern, Peter J. Southern, Maria S. Pombo-de-Oliveira

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5 Scopus citations


We present a rare case of adult T cell leukemia/lymphoma (ATL) in which leukemic T cells expressed CD4 and CD25 surface antigens and infiltrated mammary glands during clinical course of the disease. A 40-year-old male was admitted with long-standing skin lesions and leukocytosis. Peripheral blood lymphocytes were highly pleomorphic and presented CD2, CD4, CD25, CD38 membrane surface antigens. The patient proved to be seropositive for human T-cell lymphotropic virus type I (HTLV-I) antibodies. Monoclonal expansion of lymphoid cells integrated with HTLV-I genome was observed, and the diagnosis of ATL chronic type was made. He underwent a chemotherapy regimen, and skin lesions and leukocytosis improved markedly. He progressed with an indolent clinical course of ATL, when he was admitted with bilateral hyperplasia of breast, recurrent skin lesions, and leukocytosis. Breast biopsy revealed bilateral gynecomasty, extensive leukemic infiltration of typical ATL cells in the mammary glands, and the presence of mammary epithelial cells productively infected with HTLV-I. This is the first report describing invasion of the mammary tissue with HTLV-I-transformed T-cells and HTLV-I-associated breast disease. (C) 2000 Wiley. Liss, Inc.

Original languageEnglish (US)
Pages (from-to)256-259
Number of pages4
JournalAmerican Journal of Hematology
Issue number3
StatePublished - 2000


  • Adult T-cell leukemia/lymphoma
  • Breast epithelial cells
  • HTLV-I
  • Pseudogynecomasty


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