Clinical utility of one month imaging following selective internal radiation therapy

S. Young, A. Taylor, J. Golzarian, S. Flanagan, D. D'Souza, T. Sanghvi

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Purpose: The goal of this retrospective review was to determine the clinical relevance of one-month post-treatment imaging in the selective internal radiation therapy (SIRT) patient population by reporting the incidence of change in clinical management. Materials and methods: Between January 2012 and January 2016, 85 patients underwent 109 SIRT treatments for either primary or secondary hepatic malignancies. There were 59 men and 26 women with a mean age of 62.4 years (range: 39–89 years). Patients’ medical records were retrospectively reviewed for procedural, historical, laboratory and imaging information. The imaging study was considered to have changed patients’ clinical management if it resulted in the addition of a new procedure, canceling of a planned procedure or change in systemic therapy. Results: The one-month post-treatment imaging findings led to management changes in 10 of 109 (9.2%) of treatments. When evaluated by cancer type, 2/61 (3.3%) hepatocellular carcinoma (HCC) treatments had management changed while 8/48 (16.7%) non-HCC treatments underwent management change (P = 0.03). This difference was also significant at multivariate analysis (P = 0.03; odds ratio: 0.17 [0.03–082]). Conclusion: Management is rarely changed by one-month post-SIRT imaging in patients with HCC and thus is likely unwarranted. Conversely, in non-HCC patients, one month post-SIRT imaging led to a significant percentage of clinical management changes suggesting that one month imaging in this setting is likely warranted.

Original languageEnglish (US)
Pages (from-to)39-46
Number of pages8
JournalDiagnostic and Interventional Imaging
Volume100
Issue number1
DOIs
StatePublished - Jan 2019

Keywords

  • Hepatocellular carcinoma
  • Metastatic liver disease
  • Selective internal radiation therapy (SIRT)
  • Transarterial radioembolization
  • Treatment strategy

PubMed: MeSH publication types

  • Journal Article

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