Clinical Relevance of Immunobiology in Umbilical Cord Blood Transplantation

Hyun Don Yun, Ankur Varma, Mohammad J. Hussain, Sunita Nathan, Claudio Brunstein

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Umbilical cord blood transplantation (UCBT) has been an important donor source for allogeneic hematopoietic stem cell transplantation, especially for patients who lack suitable matched donors. UCBT provides unique practical advantages, such as lower risks of graft-versus-host-disease (GVHD), permissive HLA mismatch, and ease of procurement. However, there are clinical challenges in UCBT, including high infection rates and treatment-related mortality in selected patient groups. These clinical advantages and challenges are tightly linked with cell-type specific immune reconstitution (IR). Here, we will review IR, focusing on T and NK cells, and the impact of IR on clinical outcomes. Better understanding of the immune biology in UCBT will allow us to further advance this field with improved clinical practice.

Original languageEnglish (US)
Article number1968
JournalJournal of Clinical Medicine
Issue number11
StatePublished - Nov 14 2019

Bibliographical note

Publisher Copyright:
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  • Acute lymphoblastic leukemia (ALL)
  • Acute myeloid leukemia (AML)
  • Immune reconstitution
  • Leukemia free survival
  • NK cells
  • Overall survival
  • Relapse
  • T cells
  • Treatment-related mortality
  • Umbilical cord blood transplantation

PubMed: MeSH publication types

  • Journal Article
  • Review


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