Clinical Profile of Monomicrobial Corynebacterium Hip and Knee Periprosthetic Joint Infections.

Hussam Tabaja, Don Bambino Geno Tai, Elena Beam, Matthew P Abdel, Aaron J Tande

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


BACKGROUND: Corynebacterium periprosthetic joint infection (PJI) is a poorly described infectious syndrome. Prior studies included cases of polymicrobial infections. This series describes the clinical characteristics, management, and outcomes of monomicrobial Corynebacterium PJI.

METHODS: We queried the Mayo Clinic Total Joint Registry for cases of monomicrobial Corynebacterium knee and hip PJI in adults (age ≥18 years) between 2010 and 2019.

RESULTS: A total of 20 (1%) out of 2067 PJI cases met our inclusion criteria. Most were males (55%), and the median age was 64 years. Seventy percent had chronic symptoms (>4 weeks). PJI was delayed to late (>3 months postimplantation) in 90%. Three species were identified: C. striatum (70%), C. jeikeium (20%), and C. amycolatum (10%). All tested isolates were susceptible to vancomycin (100%) and linezolid (100%), and most had a minimum inhibitory concentration ≤0.06 mcg/mL to daptomycin (75%). Other agents were less reliable, with high resistance to oral agents commonly used for suppression. Nineteen patients were treated: 37% debridement and implant retention (DAIR), 47% 2-stage exchange, and 16% resection without reimplantation. Of these, failure occurred in 29%, 11%, and 0%, respectively.

CONCLUSIONS: Corynebacterium PJIs pose a therapeutic challenge due to limited antimicrobial armamentarium and undefined optimal surgical intervention. Vancomycin and linezolid remain the most reliable agents for treatment. DAIR may be attempted for acute PJI, but verification of durable chronic suppression options will be critical for this approach.

Original languageEnglish (US)
Pages (from-to)ofac193
JournalOpen Forum Infectious Diseases
Issue number7
StatePublished - Jul 2022

Bibliographical note

© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

PubMed: MeSH publication types

  • Journal Article


Dive into the research topics of 'Clinical Profile of Monomicrobial Corynebacterium Hip and Knee Periprosthetic Joint Infections.'. Together they form a unique fingerprint.

Cite this