Clinical presentation and outcome of pediatric ANCA-associated glomerulonephritis

Anne M. Kouri, Sharon P. Andreoli

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a small- and medium-sized vasculitis classically seen in adult patients, with peak onset near the fifth to seventh decade of life. There is little data on ANCA-associated vasculitis in pediatric patients, and most studies have limited follow-up. Methods: This is a retrospective chart review of 22 patients with ANCA-positive glomerulonephritis in a single institution from 1991 to 2013. Results: Of the 22 patients, eight (36 %) required renal replacement therapy (RRT) at diagnosis; four of these patients recovered sufficient renal function to initially discontinue dialysis. Five patients (23 %) were treated with plasmapheresis at presentation. The median time from presentation until first clinical or serologic relapse was 1.7 ± 1.2 years. After a median follow-up of 5.8 years, just over half of our patients had chronic kidney disease (CKD) stages 1–3 (55 %). Seven (32 %) patients progressed to end-stage renal disease (ESRD) and eventually required kidney transplant. Conclusion: ANCA-associated glomerulonephritis is a rare disorder in children. Presentation and outcomes vary significantly among patients. More research is required to follow these patients who are diagnosed in childhood to further characterize the long-term outcome of the disease.

Original languageEnglish (US)
Pages (from-to)449-455
Number of pages7
JournalPediatric Nephrology
Issue number3
StatePublished - Mar 1 2017
Externally publishedYes


  • ANCA-positive glomerulonephritis
  • Children
  • Granulomatosis with polyangiitis
  • Microscopic polyangiitis
  • Pediatric glomerulonephritis
  • Rapidly progressive glomerulonephritis

Fingerprint Dive into the research topics of 'Clinical presentation and outcome of pediatric ANCA-associated glomerulonephritis'. Together they form a unique fingerprint.

Cite this