Clinical practice guidelines and comorbid diseases: A minizinc representation of guideline models for mitigating adverse interactions

Szymon Wilk, Martin Michalowski, Wojtek Michalowski, Ken Farion, Di Lin, Marisela Mainegra Hing, Subhra Mohapatra

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Managing a patient with comorbid diseases according to multiple clinical practice guidelines (CPGs) may result in adverse interactions that need to be mitigated (identified and addressed) so a safe therapy can be devised. However, mitigation poses both clinical and methodological challenges. It requires extensive domain knowledge and calls for advanced CPG models and efficient algorithms to process them. We respond to the above challenges by describing our algorithm that mitigates interactions between pairs of CPGs. The algorithm creates logical models of analyzed CPGs and uses constraint logic programming (CLP) together with domain knowledge, codified as interaction and revision operators, to process them. Logical CPG models are transformed into CLP-CPG models that are solved to find a safe therapy. We represent these CLP-CPG models using MiniZinc, a standard language for CLP models. As motivation and illustration of our mitigation algorithm we use a clinical case study describing a patient managed for hypertension and deep vein thrombosis according to two individual CPGs. We apply the algorithm to this scenario and present MiniZinc representations of the constructed CLP-CPG models.

Original languageEnglish (US)
Title of host publicationMEDINFO 2013 - Proceedings of the 14th World Congress on Medical and Health Informatics
PublisherIOS Press
Pages352-356
Number of pages5
Edition1-2
ISBN (Print)9781614992882
DOIs
StatePublished - 2013
Event14th World Congress on Medical and Health Informatics, MEDINFO 2013 - Copenhagen, Denmark
Duration: Aug 20 2013Aug 23 2013

Publication series

NameStudies in Health Technology and Informatics
Number1-2
Volume192
ISSN (Print)0926-9630
ISSN (Electronic)1879-8365

Other

Other14th World Congress on Medical and Health Informatics, MEDINFO 2013
CountryDenmark
CityCopenhagen
Period8/20/138/23/13

Keywords

  • Adverse Drug Event
  • Clinical Practice Guideline
  • Comorbidity
  • Constraint Logic Programming
  • MiniZinc Language

Fingerprint Dive into the research topics of 'Clinical practice guidelines and comorbid diseases: A minizinc representation of guideline models for mitigating adverse interactions'. Together they form a unique fingerprint.

Cite this