Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy

Jacob T. Brown; Jeffrey R. Bishop; Katrin Sangkuhl; Erika L. Nurmi; Daniel J. Mueller; Jean C Dinh; Andrea Gaedigk; Teri E. Klein; Kelly E. Caudle; James T. McCracken; Jose de Leon; J.  Steven Leeder

doi:10.1002/cpt.1409

Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy

Jacob T. Brown, Jeffrey R. Bishop, Katrin Sangkuhl, Erika L. Nurmi, Daniel J. Mueller, Jean C Dinh, Andrea Gaedigk, Teri E. Klein, Kelly E. Caudle, James T. McCracken, Jose de Leon, J. Steven Leeder

Research output: Contribution to journal › Review article › peer-review

145 Scopus citations

Abstract

Atomoxetine is a nonstimulant medication used to treat attention-deficit/hyperactivity disorder (ADHD). Cytochrome P450 (CYP)2D6 polymorphisms influence the metabolism of atomoxetine thereby affecting drug efficacy and safety. We summarize evidence from the published literature supporting these associations and provide therapeutic recommendations for atomoxetine based on CYP2D6 genotype (updates at www.cpicpgx.org).

Original language	English (US)
Pages (from-to)	94-102
Number of pages	9
Journal	Clinical pharmacology and therapeutics
Volume	106
Issue number	1
DOIs	https://doi.org/10.1002/cpt.1409
State	Published - Jul 2019

Bibliographical note

Funding Information:
This work was funded by the National Institutes of Health (NIH) for CPIC (R24GM115264; U24HG010135-01) and PharmGKB (R24GM61374), PharmVar (R24GM123930). Atomoxetine studies conducted by the authors (J.T.B., A.G., J.C.D., and J.S.L.) have been supported by R01HD058556 and U54HD090258.

Publisher Copyright:
© 2019 The Authors Clinical Pharmacology & Therapeutics © 2019 American Society for Clinical Pharmacology and Therapeutics

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Brown, J. T., Bishop, J. R., Sangkuhl, K., Nurmi, E. L., Mueller, D. J., Dinh, JC., Gaedigk, A., Klein, T. E., Caudle, K. E., McCracken, J. T., de Leon, J., & Leeder, J. S. (2019). Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy. Clinical pharmacology and therapeutics, 106(1), 94-102. https://doi.org/10.1002/cpt.1409

Brown, JT , Bishop, JR, Sangkuhl, K, Nurmi, EL, Mueller, DJ, Dinh, JC, Gaedigk, A, Klein, TE, Caudle, KE, McCracken, JT, de Leon, J & Leeder, JS 2019, 'Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy', Clinical pharmacology and therapeutics, vol. 106, no. 1, pp. 94-102. https://doi.org/10.1002/cpt.1409

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title = "Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy",

abstract = "Atomoxetine is a nonstimulant medication used to treat attention-deficit/hyperactivity disorder (ADHD). Cytochrome P450 (CYP)2D6 polymorphisms influence the metabolism of atomoxetine thereby affecting drug efficacy and safety. We summarize evidence from the published literature supporting these associations and provide therapeutic recommendations for atomoxetine based on CYP2D6 genotype (updates at www.cpicpgx.org).",

author = "Brown, {Jacob T.} and Bishop, {Jeffrey R.} and Katrin Sangkuhl and Nurmi, {Erika L.} and Mueller, {Daniel J.} and Jean C Dinh and Andrea Gaedigk and Klein, {Teri E.} and Caudle, {Kelly E.} and McCracken, {James T.} and {de Leon}, Jose and Leeder, {J. Steven}",

note = "Funding Information: This work was funded by the National Institutes of Health (NIH) for CPIC (R24GM115264; U24HG010135-01) and PharmGKB (R24GM61374), PharmVar (R24GM123930). Atomoxetine studies conducted by the authors (J.T.B., A.G., J.C.D., and J.S.L.) have been supported by R01HD058556 and U54HD090258. Publisher Copyright: {\textcopyright} 2019 The Authors Clinical Pharmacology & Therapeutics {\textcopyright} 2019 American Society for Clinical Pharmacology and Therapeutics",

year = "2019",

month = jul,

doi = "10.1002/cpt.1409",

language = "English (US)",

volume = "106",

pages = "94--102",

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AU - Brown, Jacob T.

AU - Bishop, Jeffrey R.

AU - Sangkuhl, Katrin

AU - Nurmi, Erika L.

AU - Mueller, Daniel J.

AU - Dinh, Jean C

AU - Gaedigk, Andrea

AU - Klein, Teri E.

AU - Caudle, Kelly E.

AU - McCracken, James T.

AU - de Leon, Jose

AU - Leeder, J. Steven

N1 - Funding Information: This work was funded by the National Institutes of Health (NIH) for CPIC (R24GM115264; U24HG010135-01) and PharmGKB (R24GM61374), PharmVar (R24GM123930). Atomoxetine studies conducted by the authors (J.T.B., A.G., J.C.D., and J.S.L.) have been supported by R01HD058556 and U54HD090258. Publisher Copyright: © 2019 The Authors Clinical Pharmacology & Therapeutics © 2019 American Society for Clinical Pharmacology and Therapeutics

PY - 2019/7

Y1 - 2019/7

N2 - Atomoxetine is a nonstimulant medication used to treat attention-deficit/hyperactivity disorder (ADHD). Cytochrome P450 (CYP)2D6 polymorphisms influence the metabolism of atomoxetine thereby affecting drug efficacy and safety. We summarize evidence from the published literature supporting these associations and provide therapeutic recommendations for atomoxetine based on CYP2D6 genotype (updates at www.cpicpgx.org).

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Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy

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