Clinical-pathologic correlations in vascular cognitive impairment and dementia

Margaret Flanagan, Eric B. Larson, Caitlin S. Latimer, Brenna Cholerton, Paul K. Crane, Kathleen S. Montine, Lon R. White, C. Dirk Keene, Thomas J. Montine

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The most common causes of cognitive impairment and dementia are Alzheimer's disease (AD) and vascular brain injury (VBI), either independently, in combination, or in conjunction with other neurodegenerative disorders. The contribution of VBI to cognitive impairment and dementia, particularly in the context of AD pathology, has been examined extensively yet remains difficult to characterize due to conflicting results. Describing the relative contribution and mechanisms of VBI in dementia is important because of the profound impact of dementia on individuals, caregivers, families, and society, particularly the stability of health care systems with the rapidly increasing age of our population. Here we discuss relationships between pathologic processes of VBI and clinical expression of dementia, specific subtypes of VBI including microvascular brain injury, and what is currently known regarding contributions of VBI to the development and pathogenesis of the dementia syndrome. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock.

Original languageEnglish (US)
Pages (from-to)945-951
Number of pages7
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1862
Issue number5
DOIs
StatePublished - May 1 2016

Bibliographical note

Funding Information:
This work was supported by NIH (National Institutes of Health ), P50 AG05136 , P50 NS NS062684 , R01 AG031892 , U01 AG006781 , and U01 AG046871 .

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