Clinical insights on the use of highly sensitive cardiac troponin assays

Emil D. Missov, Teresa De Marco

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


This review describes the pathophysiological and histopathological rationale for using the cardiac isoforms of troponin T and troponin I in congestive heart failure (CHF). It also focuses on the potential clinical usefulness of new generation highly sensitive and specific cardiac troponin assays with respect to histological monitoring, risk stratification and therapeutic follow-up of patients with CHF. The availability of more powerful analytical tools for these highly specific markers of myocardial injury offers a unique opportunity to expand the field of their application and to explore new disease processes. Because cardiac troponin T and cardiac troponin I provide useful clinical information unavailable through other diagnostic techniques, they appear as promising biochemical markers in patients with CHF. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)175-185
Number of pages11
JournalClinica Chimica Acta
Issue number2
StatePublished - Jun 30 1999

Bibliographical note

Funding Information:
Dr Missov is supported in part by a grant from the Philippe Foundation.

Copyright 2007 Elsevier B.V., All rights reserved.


  • Biochemical markers
  • Cardiac troponin I
  • Cardiac troponin T
  • Congestive heart failure


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