Clinical efficacy and safety of surface imaging guided radiosurgery (SIG-RS) in the treatment of benign skull base tumors

Steven K M Lau, Kunal Patel, Teddy Kim, Erik Knipprath, Gwe Ya Kim, Laura I. Cerviño, Joshua D. Lawson, Kevin T. Murphy, Parag Sanghvi, Bob S. Carter, Clark C. Chen

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Frameless, surface imaging guided radiosurgery (SIG-RS) is a novel platform for stereotactic radiosurgery (SRS) wherein patient positioning is monitored in real-time through infra-red camera tracking of facial topography. Here we describe our initial clinical experience with SIG-RS for the treatment of benign neoplasms of the skull base. We identified 48 patients with benign skull base tumors consecutively treated with SIG-RS at a single institution between 2009 and 2011. Patients were diagnosed with meningioma (n = 22), vestibular schwannoma (n = 20), or nonfunctional pituitary adenoma (n = 6). Local control and treatment-related toxicity were retrospectively assessed. Median follow-up was 65 months (range 61–72 months). Prescription doses were 12–13 Gy in a single fraction (n = 18), 8 Gy × 3 fractions (n = 6), and 5 Gy × 5 fractions (n = 24). Actuarial tumor control rate at 5 years was 98%. No grade ≥3 treatment-related toxicity was observed. Grade ≤2 toxicity was associated with symptomatic lesions (p = 0.049) and single fraction treatment (p = 0.005). SIG-RS for benign skull base tumors produces clinical outcomes comparable to conventional frame-based SRS techniques while enhancing patient comfort.

Original languageEnglish (US)
Pages (from-to)307-312
Number of pages6
JournalJournal of neuro-oncology
Issue number2
StatePublished - Apr 1 2017

Bibliographical note

Funding Information:
This work was supported in part by National Institutes of Health Grant PHSGM007198 (UCSD Medical Scientist Training Program). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Publisher Copyright:
© 2017, Springer Science+Business Media New York.


  • Benign skull base tumor
  • Frameless radiosurgery
  • Image guided radiosurgery
  • SIG-RS
  • Stereotactic radiosurgery
  • Surface imaging guided radiosurgery


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